Composition of Panangin
The tablets contain active substances: magnesium aspartate (280 mg) and potassium aspartate (316 mg).
Additional substances: silicon dioxide, corn and potato starch, talc, povidone, magnesium stearate. The shell consists of talc, macrogol 6000, titanium dioxide, methacrylic acid copolymer. The concentrate for Panangin IV solution includes magnesium aspartate (40 mg) and potassium aspartate (45.2 mg), as well as water for injection.
results
Results. See Table 1.
In the group taking Panangin, the frequency of significant effectiveness and the overall effectiveness rate were higher than in the group taking only glipizide. Statistical analysis showed that the differences were significant (P < 0.05). The treatment did not affect the concentration of urea nitrogen, creatinine, potassium, magnesium and chlorine ions in the blood.
pharmachologic effect
What is the medicine for? It is a source of potassium and magnesium. The drug helps restore electrolyte balance, regulates metabolic reactions and processes, and has a pronounced antiarrhythmic effect.
Potassium takes an active part in synaptic transmission, in the conduction of nerve impulses along fibers, in muscle contractions, and supports the normal functioning of the heart. When potassium metabolism is disturbed, the excitability of muscle tissue and nerves changes. Active ion transport maintains a high potassium gradient across the plasma membrane. Small dosages of potassium contribute to the expansion of the coronary arteries, and in large dosages the microelement narrows their lumen. Potassium has a moderate diuretic effect, negative bathmotropic and chronotropic effects.
Magnesium is a cofactor in three hundred enzyme reactions. Magnesium is an essential element during processes and reactions that provide energy intake and expenditure. Magnesium is part of the pentose phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, and RNA synthesis; is a natural BMCA, prevents the release of free fatty acids and catecholamines during stress, and promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on intercellular phosphate synthesis.
Analogs
Asparkam
The most popular analogue of Panangin is Asparkam. This is a time-tested medicine - it has been produced for several decades.
This drug is domestically produced, its composition is completely similar to that of Panangin, while the price of Asparkam is several times lower.
The main indicator of these drugs is their effectiveness, and reviews of patients who have used both drugs indicate the high effectiveness of Panangin.
The difference between Panangin and Asparkam is that Panangin is available in dragees, and Asparkam is available in tablets.
The dragee is covered with a protective coating, so for colitis, enterocolitis, stomach diseases, and ulcers, it is better to take Panangin to protect against the active ingredient.
The main difference between these medicines is that Panangin is the original, and Asparkam is an analogue, so its effect is somewhat weaker.
Aspangin
This medicine is a complete analogue of Panangin in composition, indications, contraindications and side effects. It is available in the form of dragees, solutions for injection and for intramuscular administration, however, the effectiveness of use is somewhat weaker and less pronounced than that of Panangin.
More complete information about analogues is here, all drugs with their instructions are there, follow the link if you want to know more.
I hope this information was useful to you. Read the instructions carefully before using medications! Good health to you!
Sources: www.rigla.ru/shop/forms/panangin/ www.vidal.ru/drugs/panangin__643 compendium.com.ua/info/1034/panangin-tabletki/ upheart.org/lechenie/tabletki/instruktsiya-panangina.html
Indications for use of Panangin
Indications for the use of Panangin are as follows; the drug is prescribed:
- for hypomagnesemia , hypokalemia ;
- when taking laxatives and diuretics, glucocorticosteroids;
- for diarrhea, persistent vomiting, taking saluretics;
- for myocardial infarction, heart failure , digitalis intoxication, ventricular extrasystole , atrial extrasystole , supraventricular tachycardia , paroxysmal tachycardia .
Example of a recipe in Latin: Rp.: Dragee “Panangin” N. 20
Dosage regimen
For oral administration
Prescribe 1-2 tablets. 3 times/day. The maximum daily dose is 3 tablets. 3 times/day.
The drug should be used after meals, because the acidic environment of the stomach contents reduces its effectiveness.
The duration of therapy and the need for repeated courses are determined by the doctor individually.
For intravenous administration
The drug is prescribed intravenously as a slow infusion. A single dose is 1-2 ampoules; if necessary, repeated administration is possible after 4-6 hours.
To prepare a solution for intravenous infusion, the contents of 1-2 amps. dissolve in 50-100 ml of 5% glucose solution.
Contraindications for Panangin
The drug is not used for:
- intolerance to fructose, sorbitol ;
- impaired amino acid metabolism;
- chronic pathology of the renal system;
- hemolysis;
- exicosis;
- dehydration;
- arterial hypotension;
- myasthenia gravis;
- atrioventricular block;
- hypermagnesemia;
- hyperkalemia;
- metabolic acidosis;
- Addison's disease.
Panangin is used with caution during pregnancy.
Side effects
Side effects are the following:
- ulceration of the mucous wall of the digestive tract;
- epigastric pain;
- diarrhea;
- bleeding from the digestive system;
- drop in blood pressure;
- bradycardia;
- paradoxical reaction in the form of an increase in the number of extrasystoles;
- dry mouth, nausea, flatulence ;
- hyporeflexia;
- itchy skin;
- dyspnea;
- thrombosis;
- phlebitis;
- paresthesia;
- dizziness;
- increased sweating;
- asthenia;
- myasthenia gravis.
With rapid intravenous infusion, hypermagnesemia and hyperkalemia .
How long can you take the medicine without interruption?
The regimen for using Panangin depends on the characteristics of the condition of each individual patient. Of course, the most effective dose and frequency of administration will be selected by the treating doctor. Here we will consider the average option.
The duration of taking the drug is from one to 3 months. The average course is 4 weeks, but it can be repeated. If ion support for the work of the heart muscle is necessary, drug therapy is continued on an ongoing basis.
If necessary, Panangin is prescribed together with Riboxin (a precursor of adenosine triphosphoric acid - ATP, a compound that stores energy in the form of a special type of biochemical bond). Acting in tandem, they improve the structure of the myocardium and optimize the functioning of the heart, helping to avoid tachycardia and pathological hypertrophy of left ventricular cardiomyocytes in athletes. When taking cardiac glycosides, these drugs reduce the risk of toxic effects (for example, arrhythmias).
Instructions for use of Panangin (Method and dosage)
Panangin tablets, instructions for use
How to take the medicine? The drug is taken orally three times a day, 2 tablets. Maintenance and preventive therapy: 1 tablet three times a day, course for 3-4 weeks. In some situations, a repetition of the course of therapy is required.
Instructions for intravenous use
Panangin solution is injected intravenously, slowly. The drug is administered at a rate of 20-30 drops per minute, 1-2 times a day, 300 ml. Dosing of the drug Panangin during pregnancy is carried out according to the standard regimen of medication use.
Children can take the medicine from birth.
How to take Panangin for prevention?
If you ask the question of the benefits and harms of Panangin, you should realize that this is a drug that has its own side effects, so you should not use it for prevention. Firstly, in this way you accustom the body to a high content of magnesium and potassium, and secondly, you can provoke an overabundance of these substances, which in turn can cause a lot of negative reactions.
Pharmacokinetics
Suction -
When taken orally, absorption of the drug is high.
Removal -
excreted in urine.
Magnesium in food
Magnesium
. The total supply of magnesium in the body of a person weighing 70 kg is on average 24 g (1000 mmol); more than 60% of magnesium comes from bone tissue and about 40% from skeletal muscle and other tissues. About 1% of the total magnesium reserve in the body is found in extracellular fluid, mainly in blood plasma. In healthy adults, plasma magnesium levels range from 0.7 to 1.10 mmol/L.
The recommended dietary intake of magnesium for men is 350 mg/day, for women - 280 mg/day. The need for magnesium increases during pregnancy and breastfeeding.
Magnesium is absorbed into the gastrointestinal tract by active transport. The main regulator of magnesium balance in the body is the kidneys. 3–5% of ionized magnesium is excreted by the kidneys.
An increase in urine volume (for example, during therapy with highly effective loop diuretics) leads to an increase in the excretion of ionized magnesium. If absorption of magnesium in the small intestine is reduced, further hypomagnesemia leads to decreased excretion (<0.5 mmol/day).
Products containing potassium
Potassium
. The total potassium reserve in the body of a person weighing 70 kg is on average 140 g (3570 mmol). Its amount is slightly less in women than in men, and decreases slightly with age. 2% of the total potassium reserve in the body is located outside the cells, and the remaining 98% is inside the cells.
The optimal dietary intake of potassium is 3–4 g (75–100 mmol) per day. The main route of potassium excretion is renal (about 90% of potassium is excreted by the kidneys per day). The remaining 10% is excreted through the gastrointestinal tract. Thus, the kidneys are responsible for long-term potassium homeostasis as well as plasma potassium levels. In the short term, blood potassium levels are also regulated by the exchange of potassium between the intracellular and extracellular spaces.
Data on the pharmacokinetics of the drug in the form of a solution for intravenous administration are not provided.
Interaction
Panangin is able to enhance the negative bathmotropic, dromotropic effects of antiarrhythmic drugs.
The medication eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, and MCS.
NSAIDs, ACE inhibitors, Heparin , potassium-sparing diuretics, Cyclosporine , beta-blockers - increase the risk of developing hyperkalemia.
When using general anesthetics, the inhibitory effect of Panangin on the nervous system increases.
Succinyl chloride, decamethonium, atracuronium, suxamethonium enhance neuromuscular blockade.
The use of enveloping and astringent medications reduces the absorption of potassium and magnesium in the digestive tract.
In combination with insulin , dextrose as part of a polarizing mixture, the heart rate is normalized in case of an overdose of cardiac glycosides, in case of ectopic arrhythmias, myocardial infarction .
Panangin improves the tolerability of cardiac glycosides and is pharmaceutically compatible with their solutions.
Overdose
Symptoms:
with intravenous administration - hyperkalemia, hypermagnesemia; when taken orally, cardiac conduction disturbances occur (especially if there is pathology of the cardiac conduction system at the time of drug administration).
Treatment:
discontinuation of the drug, symptomatic therapy (iv administration of 100 mg/min calcium chloride solution), if necessary, hemodialysis and peritoneal dialysis.
Cases of overdose are unknown. Given the ability of the kidneys to excrete large amounts of potassium from the body, increasing the dose of the drug can lead to hyperkalemia only if this is associated with an acute or severe impairment of potassium excretion.
The therapeutic index of magnesium is wide, and in the absence of renal failure, severe side effects are extremely rare.
Scientific evidence suggests that taking magnesium supplements orally may cause minor side effects such as diarrhea.
High doses of Panangin may cause increased bowel movements due to the magnesium content.
In case of rapid intravenous administration, symptoms of hyperkalemia/hypermagnesemia may appear.
Symptoms of hyperkalemia: general weakness, paresthesia, bradycardia, paralysis. Extremely high concentrations of potassium in the blood plasma can lead to death from cardiac depression, arrhythmia, or cardiac arrest.
Symptoms of hypermagnesemia: nausea, vomiting, drowsiness, hypotension, bradycardia, weakness, slurred speech, double vision. At very high plasma concentrations of magnesium, hyporeflexia, muscle paralysis, respiratory arrest and cardiac arrest may occur.
In case of overdose, K+-, Mg2+-aspartate must be discontinued and symptomatic treatment is recommended (calcium chloride 100 mg/min IV, dialysis if necessary).
Panangina price, where to buy
The price of Panangin in tablets is about 150 rubles per package No. 50, the price in ampoules is about 160 rubles.
The price of Panangin in Ukraine is 110 and 140 UAH. for tablets and solution, respectively.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Panangin Forte tablets p.p.o.
316mg+280mg 60 pcs. JSC Gedeon Richter RUB 307 order - Panangin tab. p/o captivity. 158 mg + 140 mg No. 100 JSC "Gedeon Richter-RUS" RU
RUB 307 order
- Panangin tab. p/o captivity. No. 50 JSC "Gedeon Richter-RUS" RU
RUB 143 order
- Panangin conc. ready solution d/inf 45.2 mg mg/ml + 0.04 g/ml 10 ml 5 pcs CJSC PharmFirma Sotex
RUB 156 order
- Panangin conc.d/inf. 10ml n5JSC Gedeon Richter
155 rub. order
Pharmacy Dialogue
- Panangin (concentrated solution 10ml No. 5) Gedeon-Richter
145 rub. order
- Panangin (tab.p.pl.vol. 158 mg + 140 mg No. 50) Gedeon-Richter/Gedeon Richter-RUS JSC
RUB 171 order
- Panangin (tab.p.pl.vol. 158 mg + 140 mg No. 100) Gedeon-Richter/Gedeon Richter-RUS JSC
RUB 317 order
- Panangin forte (tab.pl/vol. 316mg+280mg No. 60)Gedeon-Richter
RUB 322 order
- Panangin (amp. 10ml No. 5) Gedeon-Richter
RUB 161 order
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Pharmacy24
- Panangin N50 tablets VAT "Gedeon Richter", Ugorshchina
110 UAH. order - Panangin 10 ml No. 5 concentrate for the preparation of solution for infusion VAT "Gedeon Richter", Ugorshchina
142 UAH order
PaniPharmacy
- Panangin solution d/in. 10ml No. 5 Hungary, Gedeon Richter
142 UAH order
- Panangin tablet p/captivity about. No. 50 Hungary, Gedeon Richter
115 UAH order
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