Buy Nitroglycerin sublingual tablets. 0.5 mg No. 40 in pharmacies

Nitroglycerin

The tablet should not be chewed, as an excess amount of the active substance may enter the systemic circulation through the oral mucosa. The tablets should not be swallowed.

Arterial hypotension

While taking Nitroglycerin tablets, a significant decrease in blood pressure and the appearance of dizziness are possible, especially in a standing position, with a sharp transition to a vertical position from a “lying” or “sitting” position, with a reduced volume of circulating blood, while drinking alcohol, performing physical exercises, or hot weather. If possible, patients are advised to take Nitroglycerin tablets while sitting and be careful when returning to an upright position. This reduces the risk of developing dizziness and imbalance due to dizziness caused by low blood pressure.

To reduce the risk of developing arterial hypertension, caution must be exercised when used simultaneously with drugs that have pronounced antihypertensive and vasodilating properties; stop drinking alcohol, limit your stay in rooms with high ambient temperatures (bath, sauna, hot shower), avoid taking several drugs simultaneously or sequentially within a short period of time after the first dose.

Cardiovascular diseases

When using nitroglycerin, arterial hypotension and reflex tachycardia may occur, leading to an increase in myocardial oxygen demand. These factors can lead to severe arrhythmias such as ventricular fibrillation (sometimes fatal), especially in patients with inferior wall myocardial infarction involving the right ventricle.

Arterial hypotension when using nitroglycerin may be accompanied by the development of paradoxical bradycardia and increased angina pectoris / worsening ischemia up to myocardial infarction (paradoxical nitrate reaction). The benefits of taking sublingual nitroglycerin for acute myocardial infarction or chronic heart failure have not been established. If you decide to take nitroglycerin for these conditions, you should use extreme caution. The drug should be used under strict medical supervision, with careful clinical and hemodynamic monitoring due to the possibility of developing arterial hypotension and reflex tachycardia.

Hypertrophic obstructive cardiomyopathy

In patients with hypertrophic obstructive cardiomyopathy, the use of nitroglycerin may increase the frequency of angina attacks.

Hypoxemia

In patients with alveolar hypoventilation, vasoconstriction may occur in poorly ventilated areas of the lungs and redirection of blood flow to normally ventilated areas of the lungs (Euler-Lillestrand phenomenon). The latter can occur in pulmonary diseases, as well as in patients with angina pectoris, myocardial infarction and cerebral ischemia. The vasodilating effect of nitroglycerin can lead to redistribution of blood flow into hypoventilated alveolar segments and the development of arterial hypoxemia. Ego can be a trigger for ischemia in patients with coronary heart disease. The use of nitroglycerin may worsen hypoxemia in patients with chronic lung disease or cor pulmonale.

Me themoglobinemia

With prolonged uncontrolled use of nitroglycerin, the use of high doses of the drug and in patients with liver failure, the risk of developing methemoglobinemia, manifested by cyanosis and the appearance of a brown tint of blood, increases. If cyanosis develops, it is necessary to immediately discontinue nitroglycerin and seek medical help.

Tolerance

Uncontrolled use of nitroglycerin can lead to the development of tolerance, which is expressed in a decrease in the duration and severity of the effect and the need to increase the dose of the drug to achieve a therapeutic effect. After a break in treatment, sensitivity to nitrates is restored. To prevent the development of tolerance, Nitroglycerin should be used in the smallest doses to effectively stop angina attacks.

Headache

When using the drug (usually in high doses), intense headache may occur. The severity of headache while taking nitroglycerin can be reduced by reducing the dose of the drug and/or simultaneous use of medications containing levomenthol.

Other

If blurred vision or dry mouth occurs, use of the drug should be discontinued.

During the period of use of the drug Nitroglycerin, alcohol consumption is not allowed. Nitrates can affect the results of the colorimetric determination of cholesterol concentration using the Zlatkis-Zack method (a false decrease in the concentration of total cholesterol in the blood serum).

When using the drug independently, you should not exceed the maximum duration and recommended doses. If there is no improvement in symptoms or if the symptoms of the disease worsen, you should immediately consult a doctor.

Composition of the drug and release form

The medicinal product contains:

• 1 tablet contains 0.5 mg of nitroglycerin;
• 2% as nitroglycerin on lactose.

Additional substances:

• croscarmellose sodium;
• lactose monohydrate;
• magnesium stearate;
• microcrystalline cellulose;
• povidone 25.

Nitroglycerin should only be taken as prescribed by a doctor.

The drug is available in the following forms:

• sublingual tablets of 0.5 mg nitroglycerin;
• capsules of 1 mg of 1% oil solution or 0.5 mg of this medicine;
• spray (0.4 mg – 1 dose);
• 1% alcohol solution in bottles of 5 or 10 ml.

Compatibility with other drugs:

• to enhance the effect, it is recommended to take Nitroglycerin in combination with Procainamide, vasodilators, inhibitors, beta-blockers, ethanol, antihypertensive drugs and antidepressants;

Nitroglycerin is a rather unstable compound, which, when exposed to light and heat, disintegrates and becomes unusable

• from the use of “Heparin” with “Nitroglycerin”, the effectiveness of the second decreases;
• when using Nitroglycerin with dihydroergotamine, the effect of the drug in the blood increases and blood pressure rises.

The principle of action of the medication

The main purpose of the product is to prevent and eliminate vascular spasms and pain in the cardiac region, which activate increased blood pressure, weakness and shortness of breath. After using Nitroglycerin, vasodilation occurs within 2-3 minutes, spasms are relieved and blood pressure is significantly reduced. Due to the fact that blood pressure drops quickly and sharply, you may feel powerless, lack of coordination, and dizziness.

After taking the medicine, you need to rest for some time, after which the condition will improve significantly.

Nitroglycerin is used for high blood pressure due to the following effects:

• dilation of blood vessels;
• decreased venous return of blood to the heart muscle;
• distribution of blood flow in the heart;
• reduction of ischemic destruction;
• increased systolic function;
• improvement of metabolic processes.

Nitroglycerin is an antianginal and vasodilator drug

Side effects

The drug may cause the following side effects:

• feeling of fainting;
• dizziness and headache;
• exhaustion;
• state of nausea;
• coordination disorder;
• a sharp decrease in blood pressure;
• blurred vision;
• allergy.

With continuous use, vomiting, dry mouth, upset stomach, nausea, and weakness may occur.

To mitigate side effects, it is recommended to take Nitroglycerin together with Validol or menthol. As an alternative, you can also use Votchala drops, the structure of which includes nitroglycerin.

Mode of application

In order for the therapy to be effective and safe, before using Nitroglycerin for high blood pressure, you must adhere to the following rules:

1. Capsules: bite 1 medication and place it under the tongue.
2. Tablets: Place 0.5 of the medicine under the tongue until completely dissolved.
3. Alcohol solution: drop 2 drops under the tongue or moisten a sugar cube and dissolve.
4. The spray is sprayed under the tongue.

During the reception, it is recommended to lie down or sit down in case of an attack of dizziness.

The maximum intake of tablets and capsules for an adult is 1 or ½ - one-time, daily - 5 pieces. Alcohol solution – 4 drops, per day – 16 drops.

Before using the medicine, it is advisable to take a sitting or lying position, as the medicine causes dizziness.

It is advisable to check the effect of nitroglycerin by measuring blood pressure every 15 minutes. In case the pressure has not decreased, you are allowed to take 1 more tablet or 2 drops of solution. The effect of the drug occurs within 1–2 minutes and lasts about 20–30 minutes. It is not recommended to use nitroglycerin for more than a month, as the medication can be addictive, causing it to lose its effectiveness. In this case, you can replace the drug with an analogue and consult a doctor.

Overdose

An overdose of nitroglycerin can cause the following symptoms:

• dizziness;
• fainting;
• heat or chills;
• nausea and gag reflexes;
• rise in temperature;
• weak rapid pulsation;
• increased sweating.

From the cardiovascular system, arrhythmia, hypotension, and rush of blood to the head appear

In case of overdose, the following steps should be taken:

1. Place the patient in a horizontal position.
2. Raise your lower limbs above head level.
3. Perform gastric lavage if a short period of time has passed since taking the medicine.
4. Use 1% solution of methylthioninium chloride – 1.5 ml/kg, intravenously.

Abuse of Nitroglycerin can lead to the worst consequences, including cardiac arrest, so you should use this potent drug carefully and correctly. It must be remembered that the instructions for using the medicine do not provide for targeted treatment of a hypertensive crisis.

Storage conditions

To preserve the medicinal properties of nitroglycerin, it is necessary to follow the rules for storing the drug:

1. Do not place the medication in a bright and warm place.
2. It is preferable to store nitroglycerin in the refrigerator.
3. It is required that the drug be in the package or bottle in which it was purchased.
4. After opening, the drug cannot be stored for a long time (15–20 days).
5. After two months, the effectiveness of nitroglycerin decreases by 30%.