Pharmacodynamics and pharmacokinetics
The effect of the drug on the body is due to the combination of two active ingredients bendazole and papaverine . Papaverine reduces vascular resistance and blood pressure due to the fact that it blocks the enzyme phosphodiesterase and creatine phosphokinase in blood vessels. The amount of calcium inside the cell decreases, cyclic AMP , this causes the vasodilator effect of the drug. Papaverine has an antispasmodic effect on the gastrointestinal tract and bile - and urinary tract.
Bendazole directly affects imidazole receptors of vascular smooth muscles (their walls). Thus, like papaverine, it relieves spasms, lowers blood pressure, and reduces the amount of calcium inside the cell. The substance also stimulates the activity of the spinal cord and, when taken for a long time, acts as an immunomodulator . The processes of protein and nucleic acid , antibody and phagocytosis .
What is the medicine used for and for what?
The drug has a vasodilator, antispasmodic, and vasodilator effect . In large doses it has a mild sedative effect .
Does the drug increase or decrease blood pressure?
Papazole reduces blood pressure by reducing the resistance of the vascular walls.
"Papazol": description and characteristics
The product is produced in the form of tablets, which contain 2 active ingredients: papaverine in the form of hydrochloride and bendazole (each weighing 0.3 g per tablet). The composition also contains auxiliary components - starch, talc and stearic acid.
Packaging – plastic jar or cardboard box, each containing from 10 to 60 pcs. The product can be purchased at any pharmacy without a prescription. Should be stored in a dark place at room temperature (no more than 30 degrees) within the total shelf life of 5 years from the date of production.
The drug is an antispasmodic; the active components dilate blood vessels, making it possible to stabilize (lower) blood pressure. Thus, papaverine reduces the physical resistance of the inner surface of blood vessels and neutralizes the action of the phosphodiesterase enzyme. The intracellular calcium concentration decreases, which leads to the accumulation of AMP.
This promotes a vasodilator effect, i.e. dilation of blood vessels, increasing their volume. Papaverine also leads to the elimination of spasms in the biliary tract, ureters, and ECT organs, which leads to a weakening or complete relief of pain.
Bendazole affects specific smooth muscle receptors lining the walls of blood vessels. It also eliminates spasms, which leads to lower blood pressure and a decrease in calcium concentration in cells.
Bendazole acts on the spinal cord, stimulating its work. If you take the drug for a long period, the immunomodulatory effect will be noticeable - strengthening the immune system, synthesis of antibodies, destruction of infectious agents.
Thus, “Papazol” has a complex effect on the body:
- decreased blood pressure (vasodilator effect);
- strengthening the immune system;
- vasodilation;
- preventing spasms;
- weak sedative effect (if taken in large doses).
Contraindications
- drug allergy;
- respiratory depression and epilepsy ;
- children under one year old;
- AV conduction disorder;
- liver and kidney diseases;
- hypothyroidism and head injury;
- decreased intestinal motility , some diseases of the prostate gland .
The medicine is prescribed with caution for traumatic brain injury and for pregnant and lactating mothers.
What is Papazol used for: indications
Tablets should be taken in consultation with your doctor. They are usually prescribed for the treatment of the following pathologies:
- periodic increases in blood pressure (labile arterial hypertension);
- spasms of the stomach, intestines, and other gastrointestinal organs;
- spasms of large vessels (including arteries);
- spasms of cerebral vessels;
- treatment of residual consequences of polio.
Interaction
Combination with adsorbents, astringents and drugs that coat the gastrointestinal tract .
The effect of the medicine will be enhanced when combined with sedatives , tricyclic antidepressants , antispasmodics , novocainamide , diuretics , reserpine .
The drug weakens anticholinesterase drugs , levodopa , proserin .
The toxic effect on the liver when used with nitrofurantoin is enhanced.
Contraindications and side effects
In some cases, taking the drug is limited or completely eliminated:
- children during the first year of life;
- chronic kidney disease;
- liver pathologies;
- hypothyroidism;
- significant deterioration of intestinal motility;
- epilepsy;
- depression of the respiratory system;
- certain pathologies of the representative gland;
- individual intolerance, manifestation of allergic reactions.
During pregnancy and breastfeeding, the drug is taken with caution and only in consultation with a doctor. Clinical studies on the effect of Papazol on the development of the fetus and child have been conducted in insufficient quantities, so there is no clear data. Moreover, judging by the reviews of many women, taking the drug during pregnancy is safe.
If the patient has previously suffered a traumatic brain injury, he should also take the drug only after the doctor's permission. Side effects are rare, but not excluded. In some cases, patients complain of pain in the heart area, constipation, nausea, and increased sweating. Itching, redness and other allergic reactions are also possible.
Analogs
Level 4 ATX code matches:
Tornetis
Olmax Strong
Taxier
Dynamico
Revatio
Caverject
Levitra
Cialis
Tentex Forte
Rileys
Viagra
Sildenafil
Yohimbine hydrochloride
Zidena
Dibazol, duzopharm, enelbin 100 retard, papazol-lhfz, vinoxim MV, papazol-darnitsa.
Papazole price (where to buy)
The average price of Papazole and Papazole UBF for 10 tablets (1 tablet of the drug) ranges from 7 to 12 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Papazole tablets 20 pcs. Pharmstandard-Leksredstva OJSC
69 rub. order - Papazol tab. 10pcs Pharmstandard-Tomskkhimpharm OJSC
16 rub. order
- Papazol reneval tab. 0.03yy+0.03yy 20pcs JSC PFK Update
81 RUR order
Pharmacy Dialogue
- Papazol (tab. No. 10) DHF JSC
14 RUR order
- Papazol (tab. No. 10) FS.-Tomskkhimpharm
12 RUR order
- Papazole Renewal (tab.30mg+30mg No. 20)Update of PFC CJSC
80 rub. order
- Papazol (tab. No. 20) FS.-Leksredstva
65 rub. order
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Pharmacy24
- Papazol-Darnitsa No. 10 tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
10 UAH. order
PaniPharmacy
- Papazol tablets Papazol tablets. No. 10 Ukraine, Darnitsa ChAO
11 UAH order
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Vasodilator drugs prescribed for osteochondrosis
The work of the muscles of the vascular highways is constantly regulated by nerve impulses passing through sympathetic fibers. These signals are responsible for the muscular activity of almost all internal organs and related functions.
Eliminating stagnation of blood fluid and improving microcirculation in the pathological area makes it possible to normalize metabolic processes and restore the patency of nerve impulses, as a result of which the treatment of osteochondrosis is more effective and the patient’s health condition is stabilized.
Features of the pathogenesis of osteochondrosis disease
Nowadays, osteochondrosis disease (age-related degenerative changes in intervertebral discs) is quite common among the population. This is due to a sedentary lifestyle or, on the contrary, excessively hard physical labor, back injuries, bad habits, poor diet and inadequate sleep.
Initially, the symptoms of osteochondrosis manifest themselves as minor discomfort in the back after physical activity, limited mobility, then pain syndromes become more intense and become chronic. Destructive processes in the intervertebral discs (dehydration and insufficient supply of nutrients) provoke inflammation and swelling of the pathological area (decreased blood circulation in it). The body’s protective reaction to irritation becomes even greater muscle stiffness and pain.
Soft tissue spasms compress sympathetic nerve endings and fibers, the transmission of impulses weakens, the muscle walls of blood vessels do not receive the necessary information and also find themselves in a compressed state. Poor circulation over time leads to oxygen starvation (hypoxia).
Complex conservative treatment of the spine, as a rule, includes taking vasodilating drugs. Results of action of pharmacological agents of the vasodilator group:
- normalization of blood circulation in the pathological area and throughout the body;
- improving the nutrition of soft tissues, saturating them with fluid, accelerating metabolic processes;
- reduction of inflammation and swelling of tissues, congestion and, consequently, pain;
- restoration of the passage of nerve impulses through the fibers.
Mechanisms of drug action
The group of vasodilator drugs used to treat osteochondrosis of the joints is conventionally divided into subgroups:
- substances with myotropic effects that directly affect the muscles of the vascular walls, changing their metabolic processes and reducing tone (caffeine, papaverine, no-spa);
- drugs with neurotropic effects achieve a vasodilating effect through nervous regulation of the tone of blood vessels;
- centrally acting drugs that affect the functioning of the vasomotor center located in the brain (aminazine, apessin);
- peripheral substances:
- blocking vascular adrenergic receptors (phentolamine);
- blocking the transmission of impulses (excitation) from the nerve endings of the sympathetic branches innervating the corresponding blood lines (ornid, octadin);
- improving the transmission of impulses from parasympathetic endings to blood vessels (acetylcholine, carbacholine);
- complicating the transmission of impulses in sympathetic nerve clusters, thereby reducing vascular tone (pentamine, tetamone);
- drugs with a mixed mechanism of action - central neurotropic and peripheral myotropic (nitroglycerin, amyl nitrite, reserpine, the latter weakens the sensitivity of central and peripheral adrenergic receptors responsible for the innervation of blood vessels, expands their lumen, and also lowers blood pressure).
List of main drugs prescribed for osteochondrosis
Actovegin. It has not so much vasodilating properties as stimulating tissue regeneration. It contains many nutrients: amino acids, saccharides, nucleosides. It has a positive effect on the transport, absorption and utilization of glucose and oxygen molecules, and stabilizes the plasma membranes of cells. Restores blood flow in peripheral systems, normalizes and stimulates nutrient metabolism throughout the body, develops and regenerates collaterals (small branches of blood vessels formed during compression or thrombosis of the main channel).
Eufillin. A bronchodilator, it helps relax the muscles of the bronchi, relieves spasms, dilates blood vessels, which makes it indispensable for patients suffering from asthma. Significantly improves blood circulation in the brain and peripheral vessels, and is used to treat diseases of the spine and neurological pathologies. Stimulates the action of the respiratory centers, increases the frequency and intensity of heart contractions, which makes it unsafe for patients with acute heart failure, angina pectoris and cardiac arrhythmias. Can be used for external use in the form of electrophoresis to improve blood microcirculation in pathological areas and restore trophic processes in intervertebral discs.
Pentoxifylline or trental. Improves microcirculation and regenerating properties of blood, thins the blood, reduces total peripheral vascular resistance, dilates the coronary arteries, which accelerates the transport of oxygen throughout the body. By expanding the blood vessels of the lungs, it significantly increases the tone of the muscle fibers responsible for breathing (diaphragm and intercostal muscles). Strengthens collateral blood circulation, increases the concentration of ATP in the brain, and has a beneficial effect on the bioelectrical functions of the central nervous system. The drug is contraindicated in patients with chronically low blood pressure, atherosclerosis and arrhythmia.
Xanthinol nicotinate. Improves cerebral circulation, peripheral (collateral) microcirculation, reduces the manifestations of cerebral hypoxia (insufficient oxygen supply to the brain), normalizes and improves metabolic (metabolic) processes in the brain. Thins the blood and has a beneficial effect on the functioning of the heart.
Thioctic acid, lipoic acid or berlithion. The drug is from a group of vitamin-like substances, similar to those produced by the body, and is close in biochemical properties to vitamin B group. Participates in the regulation of lipid (fat) and carbohydrate metabolism, prevents the deposition of glucose on the walls of blood vessels, improves blood flow and lowers blood viscosity. It has detoxifying properties and has a positive effect on the functions of peripheral nerves and neurovascular bundles innervating internal organs.
Medicines prescribed for cervical osteochondrosis
Symptoms of cervical osteochondrosis primarily affect the blood supply to the brain, the condition of the vertebral arteries, the vertebrobasilar circle, and then can affect the vessels and nerve endings innervating the upper limbs. They are manifested by dizziness, headaches, nausea, coordination disorders, general weakness and fatigue, disturbances in the functioning of the organs of hearing, vision, speech, and smell.
Treatment of cervical osteochondrosis quite often includes nootropic drugs (for example, piracetam, nootropil, vinpocetine), which improve blood circulation in the vessels of the head and improve metabolic processes (carbohydrate and protein) in the brain. They do not always have pronounced vasodilating properties, but they have a beneficial effect on the central nervous system, improve memory, attention, and increase productivity.
Piracetam. It has a positive effect on metabolic reactions in the body, improves blood circulation in the brain, and restores nerve cells. The drug increases energy potential through accelerated ATP metabolism, has a beneficial effect on the central nervous system and is prescribed for diseases of the blood vessels that wash the cerebral cortex.
Vinpocetine. A vasodilator, antihypoxic agent, helps to increase cerebral circulation, especially in ischemic areas by relaxing the smooth muscles of the walls of cerebral vessels. Improves oxygen transport, reduces platelet aggregation and thereby thins blood viscosity.
It is necessary to treat osteochondrosis with complex measures: medications (which, as prescribed by a doctor, may include vasodilators), physiotherapy and physical activity.
The main thing is not to endure the pain, not to delay time, but to contact osteochondrosis treatment clinics in a timely manner. Author: K.M.N., Academician of the Russian Academy of Medical Sciences M.A. Bobyr
