Nosological classification (ICD-10)
- F48.9 Neurotic disorder, unspecified
- G47.0 Disturbances in falling asleep and maintaining sleep [insomnia]
- G90 Disorders of the autonomic nervous system
- I99 Other and unspecified circulatory system disorders
- K58.9 Irritable bowel syndrome without diarrhea
- R00.0 Tachycardia, unspecified
- R10.4 Other and unspecified abdominal pain
- R45.1 Restlessness and agitation
- R45.4 Irritability and anger
Pharmacodynamics
A combined drug, the therapeutic effect of which is determined by the pharmacological properties of the components included in its composition. Has a sedative and antispasmodic effect.
Phenobarbital has sedative and mild hypnotic effects. Helps reduce central nervous system excitation and facilitate the onset of natural sleep, enhancing the sedative effect of other components.
Ethyl bromizovalerianate also has a sedative (similar to the effect of valerian) and antispasmodic effects.
Indications for the drug Valoserdin®
Valoserdin® is prescribed as a sedative and vasodilator for the following diseases and conditions:
functional disorders of the cardiovascular system;
neurosis-like conditions accompanied by increased irritability;
disturbed sleep;
tachycardia;
state of excitement with pronounced vegetative manifestations;
intestinal spasms (as an antispasmodic).
"Valoserdin" for high blood pressure: dosage and treatment regimen
Valoserdin drops are intended for oral administration. The medicine is diluted with a small amount of plain water. It is advisable to take before meals, no more than 3 times a day. The treatment regimen is selected depending on the patient’s condition.
Recommended dosage includes:
- 15-20 drops twice a day for adults suffering from nervous and vegetative-vascular disorders.
- 40-45 drops once for heart rhythm disturbances, tachycardia, heart and intestinal spasms.
The duration of therapy is determined based on the diagnosis on an individual basis. Self-medication is only permissible when feeling unwell as first aid. For hypertension, Valoserdin is taken as an additional remedy.
Drops are taken orally, dropped into a small amount of plain water.
Side effects
Valoserdin® is generally well tolerated even with long-term use. In some cases, drowsiness and slight dizziness may occur during the daytime. With long-term use of large doses, the development of chronic bromine poisoning is possible, characterized by the following manifestations: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
If any side (unusual) effects occur that are not reflected in the description, you must report them to your doctor.
Interaction
When Valoserdin® is used simultaneously with sedatives, the effect is enhanced.
Simultaneous use with neuroleptics and tranquilizers enhances, and with central nervous system stimulants, weakens the effect of each component of the drug.
Alcohol enhances the effects of Valoserdin® and may increase its toxicity.
The presence of phenobarbital in the composition can induce liver enzymes, and this makes its simultaneous use with drugs that are metabolized in the liver undesirable, since their concentration, and therefore effectiveness, will decrease as a result of more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides).
Phenobarbital weakens the effect of coumarin derivatives, corticosteroids, griseofulvin, and oral contraceptives.
How does the medicine work?
A medicinal product based on herbal components has a mild calming effect, like Valerian or Motherwort.
The drug Valoserdina contains Phenobarbital, which reduces the increased excitability of the central nervous system, improves sleep, aligning the phases of deep and restful sleep. Ethyl bromizovalerianate has a positive effect on the cardiovascular system, reduces coronary spasm and cardiac pain, and heart rate. Oil of peppermint and Spanish hops, oregano, has an antispasmodic effect, dilating blood vessels, normalizing blood flow. Combination drugs based on phenobarbital are effective for the treatment of neurovegetative disorders. Considering the presence of barbiturates and bromine in the composition, in case of overdose the drug has a pronounced hypnotic, antiepileptic and tranquilizing effect. To prevent adverse reactions, when calculating the dosage, the instructions for use of Valoserdin must be taken into account.
How long after taking does the effect appear?
Currently, the drug is available for sale in pharmacy chains in dropper bottles, with a clear liquid without a characteristic color, with a specific aromatic smell of mint and oregano essential oils. Valoserdin is not available in tablets. The medicine is an alcoholic infusion of ethyl alcohol, due to which the product is quickly absorbed after dissolving the drops in a glass of water and taking it orally. The therapeutic effect is observed within 1 - 2 hours, the peak concentration in the bloodstream remains for 3 - 5 hours, taking into account which the frequency of drug administration is calculated.
special instructions
Before starting to use the drug, you should consult your doctor.
If it is necessary to prescribe the drug during breastfeeding, the issue of stopping breastfeeding should be decided.
With prolonged use of the drug, the formation of drug dependence is possible; Possible accumulation of bromine in the body and the development of poisoning.
The drug contains at least 52 vol.% ethanol.
The maximum single dose of the drug contains 1.03 g of absolute ethyl alcohol; the maximum daily dose is 3.09 g of absolute ethyl alcohol.
Influence on the ability to drive vehicles and machinery. When using the drug, it is not recommended to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms).
Valoserdin 25ml drops for oral administration
pharmachologic effect
A combined drug, the therapeutic effect of which is determined by the pharmacological properties of the components included in its composition.
Has a sedative and antispasmodic effect. Phenobarbital has sedative and mild hypnotic effects. Helps reduce central nervous system excitation and facilitate the onset of natural sleep, enhancing the sedative effect of other components.
Ethyl bromizovalerianate also has a sedative (similar to the effect of valerian) and antispasmodic effects.
Composition and release form Valoserdin 25ml drops for oral administration
Drops – 100 ml:
- Active ingredients: phenobarbital 2 g, ethyl bromoisovalerianate (ethyl ester of α-bromoisovaleric acid) 2 g.
- Excipients: peppermint oil - 0.14 g, Spanish hop oil (oregano oil) - 0.02 g, ethanol 95% - 52.8 g, purified water - 43.04 g.
25 ml - dark glass dropper bottles (1) - cardboard packs.
Description of the dosage form
Drops for oral administration in the form of a clear, colorless liquid with a faint aromatic odor.
Directions for use and doses
As a success
The drug is taken orally, before meals, after dissolving in a small amount (30-50 ml) of water.
Adults are usually prescribed 15-20 drops 3 times a day. For tachycardia, it is possible to increase the single dose to 40-50 drops.
The duration of use of the drug is determined individually by the doctor.
Chinese remedy for intestinal spasms.
Pharmacodynamics
Reduces heart rate.
Pharmacokinetics
No pharmacokinetic data provided.
Indications for use Valoserdin 25ml drops for oral administration
- As a sedative and vasodilator for:
- functional disorders of the cardiovascular system;
- in neurosis-like conditions accompanied by increased irritability;
- disturbed sleep;
- tachycardia;
- state of excitement with pronounced vegetative manifestations.
- as an antispasmodic for intestinal spasms.
Contraindications
- Hypersensitivity to the components of the drug;
- severe renal and/or liver dysfunction;
- pregnancy;
- breastfeeding period;
- porphyria;
- age up to 18 years.
Due to the absolute ethyl alcohol content of more than 3 g in a daily dose, Valoserdin® is contraindicated in patients with liver disease, alcoholism, traumatic brain injury and other brain diseases.
Use of Valoserdin 25ml drops for oral administration during pregnancy and breastfeeding
The use of the drug during pregnancy and lactation is contraindicated.
If it is necessary to prescribe the drug during breastfeeding, the issue of stopping breastfeeding should be decided.
Use in children
The use of the drug is contraindicated in people under 18 years of age.
special instructions
Before starting to use the drug, the patient should consult a doctor.
With prolonged use of the drug, the formation of drug dependence is possible; Possible accumulation of bromine in the body and the development of poisoning.
The drug contains at least 52 vol.% ethanol. The maximum single dose of the drug contains 1.03 g of absolute ethyl alcohol; the maximum daily dose contains 3.09 g of absolute ethyl alcohol.
Impact on the ability to drive vehicles and operate machinery
When using the drug, it is not recommended to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms).
Overdose
Symptoms: with mild and moderate intoxication, drowsiness, dizziness, and psychomotor disturbances are observed. In severe cases - coma, decreased blood pressure, respiratory failure, tachycardia, vascular collapse, decreased peripheral reflexes.
Treatment: rinse the stomach, take activated charcoal and call a doctor.
Side effects of Valoserdin 25ml drops for oral administration
Valoserdin® is generally well tolerated even with long-term use.
In some cases, drowsiness and slight dizziness may occur during the daytime.
With long-term use in large doses, the development of chronic bromine poisoning is possible, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
If any side (unusual) effects occur that are not reflected in the instructions for use, the patient must inform their doctor about them.
Drug interactions
With simultaneous use of the drug Valoserdin® with sedatives, the effect is enhanced.
Simultaneous use with neuroleptics and tranquilizers enhances, and with central nervous system stimulants, weakens the effect of each component of the drug.
Ethanol enhances the effects of Valoserdin and may increase its toxicity.
The presence of phenobarbital in the composition can induce liver enzymes, and this makes simultaneous use with drugs that are metabolized in the liver undesirable, since their concentration, and therefore effectiveness, will decrease as a result of more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides and others).
Phenobarbital weakens the effect of coumarin derivatives, corticosteroids, griseofulvin, and oral contraceptives.
Valoserdin® may increase the toxicity of methotrexate.
