Medicines for male potency that do not increase blood pressure

Choosing a drug to increase potency in hypertension

Despite the fact that many popular drugs for hypertensive patients who want to increase potency remain undesirable, there are a number of medications that are free from this drawback.

This is all thanks to the composition of the products, which include mainly ingredients of plant origin and can have a gentle effect on a man’s erectile function.

Below is a list of the most effective and safe drugs.

BIG ZILLA

Big Zilla is available in the form of drops. At the moment, it remains one of the most effective – it qualitatively increases sexual desire in men.

It has a comprehensive effect on reproductive function, providing a reliable increase in potency. Safety is due to the naturalness of its components.

Includes:

• Ginseng.
• Eleutherococcus.
• Relic Ginkgo.
• Hawthorn.

These herbs and plants guarantee increased sexual activity. This effect is mainly achieved by dilating blood vessels in the corpora cavernosa of the penis, normalizing microcirculation and stimulating the production of endogenous testosterone. Like other drugs for hypertensive men to increase potency, BIG ZILLA does not lead to an increase in blood pressure.

You need to take 10-15 drops 20 minutes before intended sex or a course of 10-15 drops at night every day for 2-3 weeks. Numerous reviews from satisfied men confirm the high effectiveness of the drug. It guarantees good results without harm to health.

Strength of Maral

A domestic drug that is especially popular among hypertensive patients. The product is an excellent alternative to modern foreign capsules and tablets and is no less effective.

Qualitatively enhances potency and helps prolong sexual intercourse. And most importantly, it can be safely used by people with a tendency to hypertension. However, it still doesn’t hurt to consult a doctor first!

The composition of the drug Strength of Maral includes:

1. Pantohematogen. Main active substance. Protein that is extracted from the antlers of wild deer (deer). It is a powerful natural stimulator of testosterone synthesis.
2. Red root extract. General body stimulant. It has been used as an aphrodisiac since Russian times. Excellently increases potency without affecting blood pressure.
3. Vitamin C. A universal element that ensures stabilization of blood vessels throughout the body. An indispensable substance for hypertensive patients. Additionally strengthens the immune system.

The power of Maral is an excellent means for qualitatively improving the sexual activity of men. Sold in capsule form. The price will pleasantly surprise buyers, since it is an order of magnitude lower than foreign analogues. You need to take 1 capsule 1 time per day. The course of such treatment is 2 weeks. Additionally, you can take the drug half an hour before planned sex.

Impaza

Another fairly popular drug that almost everyone has seen in pharmacies or on TV. It should also be considered safe for hypertensive patients. No effect of the drug on blood pressure has ever been recorded.

Impaza is the development of domestic scientists. Refers to homeopathic medicines with a complex but mild effect on male strength.

After its use it is noted:

• Increased sexual desire (libido).
• Increased potency.
• Normalization of the general condition of a man.
• An increase in the amount of ejaculate during ejaculation.

All this is possible due to the unique composition of the drug, the main component of which is affinity-purified antibodies to the enzyme NO synthase. Thanks to these proteins, an increase in the amount of nitric oxide in the blood is achieved.

This substance leads to vasodilation, which increases blood flow to the penis. As a result, erection improves. However, relaxation of arteries and veins does not only occur in the penis, it affects the entire body.

Of course, Impaza cannot be used as an antihypertensive drug - its effectiveness in this regard remains insignificant. However, we can definitely say that the drug remains safe for hypertensive patients.

You need to take 1 tablet of the medicine before sex. If you want to carry out a course of therapy, then you need to take 1 piece 3 times a day

It is important not to swallow the tablets, but to dissolve or chew them in the mouth so that more of the active substance immediately enters the bloodstream

Increasing potency with drugs in hypertensive men is not a significant problem. The pharmaceutical market offers a number of good remedies to combat impotence even against the background of existing hypertension. All that remains is to choose...

Modern view on the use of sildenafil citrate

Journal "Experimental and Clinical Urology" Issue No. 1 for 2015

Efremov E.A., Kasatonova E.V., Melnik Ya.I.

Erectile dysfunction (ED) is characterized by a persistent inability to achieve or maintain an erection sufficient for successful sexual intercourse. This erectile dysfunction is widespread and according to KK Chew et al. by 2025, it is estimated to affect 322 million men worldwide [1].

Data from the latest separate study on the prevalence of ED in 6 regions of the Russian Federation were obtained in 2012 based on an analysis of survey data from 1225 respondents. When analyzing the IIEF-5 questionnaire, it was revealed that only 10.1% of surveyed men had no signs of ED, while a mild degree of ED was noted in 71.3%, a moderate degree in 6.6% and a severe degree in 12 % of respondents. Thus, out of 1225 men surveyed, symptoms of ED were present in 1101 (89.9%) respondents [2].

For many decades, treatment of ED was carried out by specialists who did not have sufficient knowledge of the pathophysiology and mechanisms of erection. Thus, in 1668, intracavernosal injections of salt solutions were first performed, then numerous options for oral therapy with various tinctures (for example, from animal testicles) were used; in the 19th century, subcutaneous injections of ejaculate were proposed; in 1936, the first penile implantation was performed [3 ].

Currently, in the treatment of ED, the polyetiological nature of the disease is taken into account, but the first line of therapy, despite the variety of causes of ED, are phosphodiesterase type 5 inhibitors (PDE-5 inhibitors). The noninvasive nature of PDE5 inhibitor therapy has increased the availability of treatment compared to other treatment modalities, which include intracavernous injections of vasoactive drugs, vacuum devices, penile prostheses, and surgical vascular reconstructions [3].

The history of the use of PDE-5 inhibitors began in March 1998, when the drug sildenafil was approved for use by the Food and Drug Administration (FDA) in the United States of America. With the appearance on the market of this first effective tablet drug for the treatment of ED, sildenafil rightfully became the flagship and gold standard of first-line treatment for ED. Vardenafil and tadalafil, which were introduced somewhat later, are also known as selective PDE5 inhibitors. Thus, sildenafil is the most studied drug among PDE-5 inhibitors in terms of safety and effectiveness.

Sildenafil citrate provides an increase in the concentration of cyclic guasine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum of the penis, which, in turn, leads to an increase in the level of nitric oxide (NO) in these cells and, as a result, to the relaxation of these cells and increased blood flow in the penis. When the NO-cGMP chain is activated, which is observed during sexual arousal, inhibition of PDE5 leads to an increase in cGMP in the corpus cavernosum. The pharmacological effect is achieved only in the presence of sexual stimulation [4].

USE OF SILDENAFIL IN PATIENTS WITH CARDIOVASCULAR DISEASES

In the American Massachusetts Male Aging Study, the incidence of ED in men aged 40-70 years was 52%. In the German study Cologne Male Survey, when analyzing the population, the incidence of ED was 10% in men aged 40-49 years, 16% in men aged 50-59 years, 34% in men aged 60-69 years and more than 50% in men aged from 70 to 80 years [5-7]. Thus, the main group of patients with erectile dysfunction are men over 50 years old; at this age, the incidence of cardiovascular diseases, including myocardial infarction and stroke, increases. Sexual dysfunction in men with cardiovascular disease is common. Many patients stop sexual activity due to fear that physical efforts during sexual activity will be complicated by recurrent myocardial infarction. However, there are a number of studies proving the safety and effectiveness of sildenafil citrate in a group of patients with ED and cardiovascular diseases [8-9].

In a phase II/III, double-blind, open-label study conducted by the FDA, more than 3,700 patients received sildenafil for ED and nearly 2,000 received placebo. Approximately 25% of patients had hypertension and were taking antihypertensive drugs, and 17% had diabetes. In these studies, the incidence of major cardiovascular events was similar in the sildenafil and placebo groups. 28 patients who suffered myocardial infarction during the study were registered. The incidence of myocardial infarction was 1.7% in the sildenafil group and 1.4% in the placebo group. There were no differences in the incidence of cardiovascular disease between the two groups, and no deaths were related to treatment. Histomorphological studies did not find any traces of PDE-5 inhibitors in the area of ​​necrosis and tissue of the ventricles of the heart, but traces of PDE-5 inhibitors were found in the atria [10].

In studies by M. Guazzi et al. It was found that sildenafil improves the condition of the endothelium. The authors noted flow-dependent dilatation of the brachial artery in patients with heart failure and type 2 diabetes mellitus [11].

In patients with heart failure due to ischemic or non-ischemic heart disease without pulmonary disease, a single dose of 50 mg of sildenafil caused a significant increase in cardiac index and a decrease in pulmonary vascular resistance both at rest and during exercise. In patients with coronary artery diseases, a positive effect of sildenafil on skin microcirculation has been established [12].

The vasodilator effect of sildenafil affects both arteries and veins, so the most common side effects are headache and facial flushing. Sildenafil causes a slight decrease in systolic and diastolic blood pressure, but clinically significant hypotension is rare, while co-administration of sildenafil and nitrates causes a more significant drop in blood pressure. For this reason, sildenafil is contraindicated for use in patients within 24 hours after taking short-acting nitrates. Meanwhile, about 5.5 million men require constant intake of nitrates, which leaves the question of further research on the joint use of these substances open [9].

USE OF SILDENAFIL IN PATIENTS WITH DIABETES MELLITUS

In the practice of a therapist, a pressing issue is the use of sildenafil for diabetes mellitus, since in patients suffering from type 1 and type 2 diabetes mellitus, erectile dysfunction occurs three times more often than in the general patient population. Moreover, erectile dysfunction can be considered as an early marker of diabetes mellitus. Thus, 12% of men suffering from erectile dysfunction were diagnosed with diabetes mellitus for the first time during examination. An additional 50% are expected to develop ED within 5–10 years of diagnosis [13]. The mechanism of ED in men with diabetes mellitus is predominantly caused by organic factors: vasculogenic and neurological. Goldstein et al. A study of sildenafil citrate 50 mg in patients with diabetes reported a 52% improvement in erectile function compared with placebo [14]. Similar data were obtained by MS Rendell et al. They noted an improvement in erectile function in 56% of patients taking sildenafil at a dosage of 100 mg versus 10% in the placebo group. Thus, sildenafil is effective and well tolerated in the treatment of organic ED in men with diabetes mellitus [15].

USE OF SILDENAFIL IN PSYCHOTHERAPY PRACTICE

Erectile dysfunction is a polyetiological disease and in some cases can be caused by various psychogenic factors that require specialized therapy. ED can both cause depression and be its consequence.

It has been noted that with monotherapy with antidepressants, antidepressant-induced ED occurs in 37% of cases, manifested by decreased libido, difficult ejaculation and anorgasmia. In a 12-week randomized, double-blind, placebo-controlled study in 20 urology clinics, the effect of sildenafil on erectile dysfunction in men with mild to moderate depressive disorders was assessed. Not only has sildenafil been shown to be an effective drug for the treatment of erectile dysfunction, but it has also been associated with a marked reduction in depressive symptoms and an improvement in quality of life: 60 (90.9%) of 66 men taking sildenafil reported that the treatment improved their erections and 59 (89.4%) %) noted an improvement in the ability to perform sexual intercourse, compared with 8 (11.4%) and 9 (12.9%) of 70 men receiving placebo, respectively [16-17].

A meta-analysis of 9 randomized studies was conducted involving 398 men with ED of mixed etiology who received various treatments: 141 patients used psychotherapy only, 109 only sildenafil, 68 patients used psychotherapy in combination with sildenafil, 20 people used vacuum devices and 59 people included to the control group. The best rates of successful treatment were obtained for a group of patients in which psychotherapeutic treatment was combined with sildenafil [18].

Another study assessed the effect of sildenafil on couple mental health using the Self-Esteem And Relationship (SEAR) questionnaire. According to the results of the survey, after a year of taking the drug, indicators such as general well-being, self-control, and satisfaction in relationships increased significantly. The authors recommend taking the drug to improve the overall mental health of not only the man, but also the couple as a whole [19].

SELECTED ISSUES OF THE APPLICATION OF SILDENAFIL IN VARIOUS UROLOGICAL DISEASES

Currently, the world has extensive experience in the use of sildanafil for various urological diseases complicated by ED.

Lower urinary tract dysfunction and ED

There are several clinical studies demonstrating the effectiveness of PDE5 inhibitors in the treatment of lower urinary tract dysfunction (LUTS). JP Mulhall et al. studied the effect of sildenafil on LUTS in men referred for sexual dysfunction. After the administration of sildenafil, 60% improved their IPSS questionnaire scores. The mean decrease in IPSS scores per week was 2 ± 0.6. The authors concluded that sildenafil helps improve urination in men with mild to moderate forms of LUTS and ED [20].

Many studies have been devoted to studying the role of PDE-5 inhibitors in combination with α-blockers in improving sexual function. SAKaplan et al. reported the results of their experimental work demonstrating the safety and effectiveness of combination treatment with the blocker alfuzosin and sildenafil compared with monotherapy groups in the treatment of LUTS and ED. After 12 weeks of therapy, patients in all groups showed an improvement in IPSS, Qmax and IIEF scores, but the best results were obtained in the combination therapy group. The researchers concluded that treatment with sildenafil in combination with an adrenergic blocker was safe and effective in the treatment of both LUTS and ED [21]. In another randomized, double-blind, placebo-controlled study performed by K. McVary et al. similar results were noted. In this 12-week study, 366 men over 45 years of age with IIEF-5 scores less than 25 and IPSS scores greater than 12 received sildenafil 50 and 100 mg or placebo. The results showed a reduction in mean IPSS score of 6.32 points in the sildenafil group compared to 1.93 in the placebo group. On the IIEF-5 scale, an improvement in the mean score was found by 9.17 compared to 1.86 points when taking placebo (p < 0.0001) [22].

Thus, the use of sildenafil, either alone or in combination with alpha-blockers, has demonstrated efficacy and safety in the treatment of LUTS caused by benign prostatic hyperplasia (BPH) and erectile dysfunction.

Prostate Cancer and ED

Treatment of erectile dysfunction with sildenafil in patients undergoing radiation therapy for prostate cancer (PCa) was initially shown to be effective in uncontrolled studies and later confirmed in a controlled study. 50 patients with ED after radiation therapy for localized prostate cancer took 50 mg of sildenafil. At the same time, a significant improvement in erection was noted by 66-74% of patients [23, 24].

The most significant prognostic factors for the restoration of erectile function after radical prostatectomy are bilateral preservation of the neurovascular bundles and the absence of erectile disorders before surgical treatment. According to M. Tutolo et al. The effectiveness of sildenafil for the treatment of ED in 170 men after radical nerve-sparing prostatectomy was 80% [25]. In a randomized, double-blind, placebo-controlled study, H. Padma-Nathan et al. report that early administration of a PDE5 inhibitor increases the recovery of spontaneous erections, with the effectiveness of sildenafil increasing over time, with better results observed 12–24 months after surgery [26].

Pelvic trauma and ED

Injuries to the pelvis and perineum can cause erectile dysfunction. PJ Harwood et al. noted that as a result of pelvic fracture and urethral injury, 30% and 42% of patients, respectively, had erectile dysfunction [25]. OZ Shenfield et al. reported that after urethroplasty, the administration of sildenafil at a dosage of 100 mg significantly reduced the manifestation of ED in 47% of patients. It has been noted that the drug is most effective for injuries of the genitourinary organs with preserved innervation and blood supply [27-28].

Fertility and ED

Equally important is the assessment of the effect of sildenafil on male fertility. After sildenafil entered the pharmaceutical market, many scientific works were devoted to studying the effect of the drug on the characteristics of sperm in vitro. Research by A.O. Kulikova et al., conducted at the Federal State Budgetary Institution "Research Institute of Urology" of the Ministry of Health of Russia in 2013, showed that in vitro conditions revealed a sharp increase in total sperm motility (A + B) when exposed to sildenafil at a concentration of 25 ng/ml (p < 0.001 ) and a tendency towards inhibition of general mobility (A+B) at drug concentrations above 250 ng/ml (p=0.09). This may indicate the presence of a stimulating effect on spermatogenesis and sperm maturation at a low dose of the drug. According to the data obtained, the author recommends avoiding maximum therapeutic dosages of sildenafil in patients planning pregnancy [29].

Currently, in addition to the original drug sildenafil, a generic Erexezil, produced in Hungary, has appeared on the Russian market. The results of the studies show that the effectiveness and safety of the drug Erexesil is comparable to that of the original drug [30]. Studies have noted a significant positive effect of Erexesil on erectile function. There was an improvement in the quality of life of patients taking this drug [31]. Available release forms of 50 mg and 100 mg No. 1 and No. 4 allow effective dosing of the drug, which ensures an individual approach to the treatment of each patient.

LITERATURE

1. Chew KK, Earle CM, Stuckey BGA, Jamrozik K, Keogh EJ. Erectile dysfunction in general medicine practice: prevalence and clinical correlates. // Int J Impot Res. 2000. Vol. 12. P. 41–45.
2. Pushkar D.Yu., Kamalov A.A., Al-Shukri S.H., Erkovich A.A., Kogan M.I., Pavlov V.N., Zhuravlev V.N., Bernikov A.N. Analysis of the results of an epidemiological study of the prevalence of erectile dysfunction in the Russian Federation // Urology. 2012. N 6. P. 5–9.
3. Jonas U. The history of erectile dysfunction management. // Int J Impot Res. 2001. Vol. 3. P. 3-7.
4. Boswell-Smith V, Spina D, Page CP. Phosphodiesterase inhibitors. //Br J Pharmacol. 2006. Vol. 147. P. 252–257.
5. Stolk EA, Busschbach JJ. Are patients and the general public likeminded about the effect of erectile dysfunction on quality of life? // Urology. 2003. Vol. 61, N 4. P. 810-815.
6. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. // J Urol. 1994. Vol. 151, N 1. P. 54-61.
7. Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U. Epidemiology of erectile dysfunction: results of the “Cologne Male Survey”. // Int J Impot Res. 2000. Vol. 12, N 6. P. 305-311.
8. Cakir O. The frequencies and characteristics of men receiving medical intervention for erectile dysfunction: Analysis of 6.2 million patients. // 28th Annual EAU congress, 15-19 March, 2013. Milan. Italy, abst. N 126.
9. American Heart Association. 1998 Heart and Stroke Statistical Update. Dallas, Tx: American Heart Association; 1997.
10. Zusman RM. Cardiovascular data on sildenafil citrate. // Am J Cardiol. 1999. Vol. 83(1). P. 44.
11. Guazzi M, Tumminello G, Di Marco F, Guazzi MD. Influences of Sildenafil on lung function and hemodynamics in patients with chronic heart failure. //Clin Pharmacol Ther. 2004. Vol. 76. P. 371–8.
12. Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. // Circulation. 2007. Vol. 115. P. 59-66.
13. Shabsigh R, Perelman M, Lue TF, Broderick GA, Lockhardt D. Men's health issues: prevalence and correlates of erectile dysfunction. //Jurol. 2005. Vol. 174. P. 662–667.
14. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. //N Engl J Med. 1998. Vol. 338. P.1397-1404.
15. Rendell MS, Rajfer J, Wicker PA, Smith MD. Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. // JAMA. 1999. Vol. 281, N 5. P. 421-426.
16. Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC. Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. //Am J Psychiatry. 2001. Vol. 158. P. 1623–1630.
17. Zajecka J, Mitchell S, Fawcett J. Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the Rush Sexual Inventory. //Psychopharmacol Bull. 1997.Vol. 33. P. 755-760.
18. Melnik T, Soares B, Nasello AG. Psychosocial interventions for erectile dysfunction. //Cochrane Database of Systematic Reviews. 2007. Vol 3.
19. O'Leary MP, Althof SE, Cappelleri JC, Crowley A, Sherman N, Duttagupta S. Selfesteem, confidence and relationship satisfaction of men with erectile dysfunction treated with sildenafil citrate: a multicentre, randomized, parallel group, double-blind, placebo controlled study in the United States. // J Urol. 2006. Vol. 175. P. 1058–1062.
20. Mulhall JP, Guhring P, Parker M, Hopps C. Assessment of the impact of sildenafil citrate on lower urinary tract symptoms in men with erectile dysfunction. //J Sex Med. 2006. Vol. 3, N 4. P. 662-667.
21. Kaplan SA, Gonzalez RR, Ogiste J, et al. Combination of an alpha-blocker, alfuzosin SR, and a PDE-5 inhibitor, sildenafil citrate, is superior to monotherapy in treating lower urinary tract symptoms (LUTS) and sexual dysfunction. //Jurol. 2006. Vol.175, Suppl. 4 P. 528. Abstract 1638
22. McVary K, Camps J, Henry G, Camps JL, Jr, Young JM, Tseng LJ, van den Ende G. Sildenafil improves erectile function and urinary symptoms in men with erectile dysfunction and concomitant lower urinary tract symptoms. // J Urol. 2006. Vol. 175, Suppl. 4. P. 527–528. Abstract 1637
23. Zelefsky MJ, Mckee AB, Lee H, Leibel SA. Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. //Urology. 1999. Vol. 53. P. 775–778.
24. Merrick GS, Butler WM, Lief JH, Stipetich RL, Abel LJ, Dorsey AT. Efficacy of sildenafil citrate in prostate brachytherapy patients with erectile dysfunction. //Urology. 1999. Vol. 53. P. 1112–1116.
25. Tutolo M, Briganti A, Suardi N, Gallina A, Abdollah F, Capitanio U, Bianchi M, Passoni N, Nini A, Fossati N, Rigatti P, Montorsi F. Optimizing postoperative sexual function after radical prostatectomy. // Ther Adv Urol. 2012. Vol. 4, N 6. P. 347-365.
26. Padma-Nathan H, McCullough AR, Levine LA, Lipshultz LI, Siegel R, Montorsi F, Giuliano F, Brock G; Study Group. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve sparing radical prostatectomy. // Int J Impot Res. 2008. Vol. 20, N 5. P. 479-86.
27. Harwood PJ, Grotz M, Eardley I, Giannoudis PV. Erectile dysfunction after fracture of the pelvis. // J Bone Joint Surg Br. 2005. Vol. 87, N 3. P. 281-90.
28. Shenfield OZ, Gofrit OD, Gdor Y, Landau I, Katz R, Pode D. The role of sildenafil in the treatment of erectile dysfunction with pelvic fracture urethral disruption. // J Urol. 2004. Vol. 172. P. 2350–2352
29. Kulikov A.O. The influence of phosphodiesterase type 5 inhibitors on spermatogenesis: Diss. Ph.D. honey. Sci. Moscow. 2013. 178 p.
30. Randomized, open label, 2-way crossover, bioequivalence study of sildenafil 100 mg tablet and Viagra (reference) following a 100 mg dose in healthy subjects under fasting conditions. // Final integrated clinical and statistical report. Version Date: 2007-02-26.
31. Instructions for medical use of the drug Erexesil. // URL: https://www.egis.ru/images/science/bioequivalencestudy_2007.pdf

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Journal "Experimental and Clinical Urology" Issue No. 1 for 2015

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Review of the most effective means

The most effective and safe drugs for the treatment of impotence in hypertension:

Dapoxetine (Priligy)

10 film-coated tablets, 60 mg, in blisters. Price: from 1,000 rubles per package (5 tablets).

Contraindications: allergies to the active substance or other components, heart disease, lactose intolerance, concomitant use of MAO inhibitors, thioridazine and some other drugs, disorders of the kidneys and liver. The medicine is not intended for women and patients under 18 years of age. It is not recommended to use simultaneously with narcotic or sedatives, or with alcohol.

Alprostadil

Ampoules 0.02 mg (20 mcg) alprostadil, 10 pieces per package (used intravenously and intra-arterially). Price: from 5,700 rubles.

Contraindications: allergy to the active substance or other components, myocardial infarction, angina pectoris, arterial hypotension, cardiovascular failure, renal dysfunction, increased blood viscosity, balanitis, urethritis, arterial hypotension, diabetes mellitus, etc.

Phentolamine

Tablets of 0.025 g, 30 pieces in a package; ampoules of 1 ml containing 10 mg of the active drug. Price: currently not on sale in Russia, Ukraine and Kazakhstan. Analogues - Regitin, Rogitin, Dibazin.

Contraindications: allergy to the active substance or other components, myocardial infarction (including a history), ischemia, cardiogenic shock, low blood pressure, angina pectoris.

Papaverine

Release form: tablets of 0.01 g or 0.04 g in blisters of 10 pieces; solution for injection 2% in ampoules of 2 ml (10 pieces per package). Price: tablets – 10 rubles; 10 ampoules for injection – 35 rubles.

Contraindications: elderly and children, glaucoma, individual intolerance to components, liver and kidney failure, hypothyroidism, tachycardia, etc.

We advise you to study - Royal jelly for men: beneficial properties and harm

Vasoton (L-Arginine)

Is a dietary supplement. Release form: capsules of 500 mg, 50 pcs. in a bottle; capsules 1000 mg, 90 pcs. in a bottle. Price: from 220 rubles per capsule.

Contraindications: individual intolerance, herpes, schizophrenia, pregnancy and lactation.

Impaza

Homeopathic remedy. Release form: lozenges of 10, 20 or 40 pcs. packaged. Price: from 385 rubles per tablet.

Contraindications: intolerance to the constituent components of the drug, lactose intolerance.

Tribestan

Release form: film-coated tablets, 250 mg. 10 pieces. 6 or 18 blisters in a cardboard box. Price: on average 2,730 rubles.

Contraindications: pregnancy, lactation, age under 18 years, intolerance to the drug components.

Verona

Release form: capsules of 20 or 60 pieces in a polymer bottle, 1 bottle is included in a cardboard box. Price: from 320 rubles per capsule.

Contraindications: hypersensitivity to the components of the drug.

Can Aspirin improve potency?

Aspirin, or acetylsalicylic acid, is a tableted drug with antipyretic, anti-inflammatory and analgesic properties.

It is used to eliminate painful sensations of various etiologies, as well as to relieve fever, inflammation and for blood thinning purposes.

Recently, there has been more and more information that aspirin tablets are used to increase the potency of men and eliminate disorders of the erectile functionality of the penis.

In the materials of the presented review, we will consider in detail what kind of connection exists between male potency and acetylsalicylic acid and how it can affect male strength.

The effect of aspirin on male potency

There are several opinions regarding the effect of this drug on men's health, and they all fundamentally contradict each other.

Some argue that aspirin for impotence is a very effective remedy that promotes the rapid restoration of male sexual capabilities of the body, while others, on the contrary, insist on the harmfulness of this drug and that it contributes to a decrease in male strength.

So, let’s take a closer look at how acetylsalicylic acid actually acts on the male body. The fact is that this medication can affect the level of potency, both positive and negative.

Acetylsalicylic acid has a positive effect on the male body by thinning the blood in the cavities of blood vessels and restoring the intensity of blood microcirculation processes, as well as preventing the formation of blood clots.

Thus, the effectiveness of the drug in relation to men's health is observed only with the development of erectile dysfunction, formed against the background of vascular pathologies.

This is due to the fact that with the vascular nature of the decrease in male power, aspirin increases potency by normalizing the blood supply to the cavernous bodies in the cavity of the penis, against the background of which an enhanced and rapid erection occurs.

Men who took a daily tablet drug with a concentration of 100-300 mg per day for three months in order to increase erectile functionality and restore the sexual capabilities of their body, eventually noted that their sexual desire for the opposite sex increased noticeably.

And, as for potency, during the course of taking the drug, the number of successful sexual contacts they had almost tripled, which, of course, cannot but rejoice.

People’s opinion that aspirin should not be taken to increase potency, since it only causes harm to the body, is based on the fact that aspirin is a non-steroidal anti-inflammatory drug. And such drugs, as is known, have a wide range of contraindications. In case of overdose and with prolonged course use, they can cause serious side effects.

Some sources report that this medication helps reduce potency, erectile functionality of the penis and libido, but supporters and opponents in the same quantity can be found even for ordinary ascorbic acid.

Method of using aspirin to increase potency

The anticoagulant properties of aspirin make it possible to use it to improve male potency, enhance erectile functionality and increase libido levels.

Moreover, this drug restores blood microcirculation processes, normalizing metabolic reactions, as well as tissue trophism and their level of functionality in the cavity of the male genital organ.

But to get the most effective therapeutic benefit from aspirin, it must be taken in accordance with the following recommendations:

1. In no case should you exceed the daily dose of the drug of 100-300 mg, therefore, if you purchased regular acetylsalicylic acid in tablets with a dosage of 500 mg, then you should drink no more than half of one tablet per day.
2. The course of taking aspirin should be at least 2-3 months.
3. And most importantly, before you start taking this medication, you must first consult with your doctor to determine the presence or absence of possible contraindications.

It is important to remember that you should not self-medicate impotence, since an incorrectly selected treatment regimen may not only not give the expected results, but also cause the development of serious side effects

Drugs to improve erectile function

The fastest way to get your erection back and prolong sexual intercourse is to take a medicine that enhances erections. But you should not abuse medications, as they are addictive and have certain contraindications and side effects.

Pills

If problems with erection occur rarely, there are no chronic diseases, you can take stimulants in the form of tablets - they act quickly, the therapeutic effect lasts for several hours. To avoid counterfeits, you can first look at the photo to see what the medicines look like.

List of effective drugs:

1. Viagra is one of the most popular drugs for improving potency and libido. It is better to drink the medicine before meals, about an hour before sexual intercourse, no more than 1 time per day. The drug can cause a persistent erection within half an hour, the effect lasts for about 4 hours.

Cialis is a medicine intended to treat impotence and improves erection. If sexual intercourse occurs more than 2 times a week, you need to drink 5 mg every 24 hours, with reduced sexual activity - 20 mg a quarter of an hour before sex, the penis remains hard for up to 36 hours, which allows you to have sex all night. Find out the price of Cialis

We advise you to study - Phosphodiesterase type 5 inhibitors: drugs for men

Cialis is an effective remedy for improving erection

1. Levitra is one of the cheapest pills for improving potency; it provides a stable erection for up to 8 hours due to the dilation of the blood vessels of the penis. They should be taken 30–60 minutes before sexual intercourse, regardless of food intake, no more than 1 time per day.
2. Impaza is a Russian drug against impotence and is considered one of the safest medications. It is necessary to dissolve 2 tablets before sex 1-2 hours before sex. With regular use, significant improvements are observed within 6–8 weeks, erections are normalized, and libido increases.

Impaza - a Russian remedy for impotence

Important! Potency pills should not be taken if you have problems with the heart, blood vessels, liver, ulcers, or hypotension. The medicine is not recommended to be combined with alcohol and fatty foods.

Ointments

External products are safer than tablets, but their effect is shorter, so they should be applied 5-15 minutes before sexual intercourse.

Creams and gels for potency:

1. Maxoderm - contains herbal extracts, grapefruit seed extract, vitamins, zinc. After application, a persistent and long-lasting erection occurs, the corpora cavernosa are filled with blood, which helps to increase the size of the penis, the cream increases the sensitivity of the erogenous zones. It must be used regularly, for at least 3 months.
2. Med 2002 - ointment has an antibacterial, analgesic, and stimulating effect. It should be applied immediately before sexual intercourse; it can be used instead of a lubricant. Disadvantages - the composition contains many synthetic ingredients.
3. Himcolin is a gel, ointment or cream based on natural ingredients. The drug stimulates erection, increases arousal, and aggravates sensations. It must be applied daily for at least 2 weeks, even if there is no coitus, it will help get rid of sexual impotence.

Himcolin - ointment to increase erection

A short, but powerful and persistent erection can be obtained after applying regular nitroglycerin or heparin ointment to the penis. They quickly dilate blood vessels, activate blood circulation, and are low cost and safe.

Drops and dietary supplements

The drops are distinguished by their natural composition, cumulative effect, and ease of use.

Drops Thor's Hammer - the composition contains many vitamins and microelements, the drug helps get rid of erectile dysfunction, premature ejaculation, enhances libido, improves the quality of seminal fluid, promotes testosterone synthesis. You need to take 3-5 drops once a day for 15-30 days. Dietary supplement is not a medicine.

Thor's Hammer drops consist of natural ingredients

Tornado drops – have a stimulating, tonic, and general strengthening effect; the dietary supplement contains guarana extract, arginine, glycine, and magnesium. The drug stimulates erection, helps prolong sexual intercourse, improves blood circulation in the penis, and is safe for prostate pathologies. You need to take 5 drops daily for 2 weeks.

The connection between hypertension and potency in men

The culmination of sexual intimacy for a man is an erection.
It is accompanied by a strong rush of blood to the genital organ with subsequent outflow. The problem arises due to the fact that in hypertensive patients the blood vessels are less elastic than in healthy men and their blood flow is slower.

Even when experiencing a strong desire, a man with high blood pressure often does not have a normal, persistent erection. According to statistics, almost half of all hypertensive men experience difficulties in this regard. Due to hypertension, blood vessels lose the ability to contract and unclench when needed. The erection becomes sluggish and short-lived.

Hypertensive patients can be sexually active:

1. limiting oneself in loads during intimate contact;
2. taking a more passive position in sex;
3. entering into a relationship with an active partner who prefers “upper” positions.

The decrease in male libido is greatly influenced by addiction to bad habits and other concomitant diseases.

Scientists' opinions

Conducting studies of mature patients, researchers found that one of the factors provoking sexual failure in men is precisely high blood pressure.

• In men over 40 years of age, impotence develops due to hypertension.
• It can also be caused by taking blood pressure pills.

The deposition of plaques inside the blood vessels from which the arteries arise leads to a decrease in the tension of the male sexual organ, causing a weak erection. University professors estimate that 45% of men cannot function normally during sexual intercourse due to plaque and salts inside the arteries, and the remaining 55% have acquired sexual dysfunction due to taking medications for hypertension.

Potency pills without side effects

Levitra

Levitra

The main component that affects the body is vardenafil. Dissolves in the mouth, providing quick action. These potency drugs are effective for erectile dysfunction of any severity and are suitable for patients of all ages, including those with disorders of the cardiovascular system. Men note that the pills do not fail, allow you to increase the duration of sexual intercourse, and maintain the penis in a state of tone. Levitra is well tolerated and has minimal side effects.

Viagra

The most famous drug for male potency from this group, which does not increase blood pressure. Increases blood flow, fills the cavernous bodies of the penis with blood, bringing it to the state necessary for making love. You can take Viagra no more than once a day, one hour before sexual intercourse. The disadvantage of the product is its relatively short duration of action - up to five hours. Attempts to increase the dose pose a threat to life. Side effects when taken correctly are rare and do not affect your health. There may be increased irritability, redness of the skin of the neck and face, swelling of the nose, headache, and dyspeptic symptoms.

Cialis

A harmless drug for improving potency, superior in quality to Viagra, it does not increase blood pressure. The effect can last up to 36 hours. All this time, a representative of the stronger sex can successfully engage in sexual intimacy. For maximum effect, it is enough to take no more than 20 milligrams of the drug 15 minutes before sexual intercourse. Minor side effects may include migraines or mild dyspepsia, local muscle pain, and skin redness. In most cases, negative manifestations do not disrupt the usual way of life and disappear with prolonged use of the drug.

dietary supplements

Lingzhi mushroom

Not registered as medicines, are of plant origin. The most popular additives: deer antlers, tuberous onion seeds, ginseng, lingzhi mushroom, Chinese wolfberry. The disadvantage of dietary supplements is their unproven stimulating effect, which has not been confirmed by research. Allergic reactions are possible. The duration of treatment can last up to six months.

Impaza

This is the safest product and easy to use. It can be used for heart diseases. After a course of therapy, the effect lasts for more than several months.

High risk of complications

If a man ignores high blood pressure and continues to stimulate an erection, then the likelihood of developing serious complications increases. Since the onset of sexual arousal and sexual intercourse increases the stress on the body, the patient may suffer from:

• myocardial infarction
• ischemic stroke
• exacerbation of kidney pathologies
• angina attack
• pulmonary edema
• acute heart failure
• encephalopathy