Managing high cholesterol and other blood lipids

The best pills to lower blood cholesterol.

May 13, 2021
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Content

• Atoris
• Livazo
• Ezetrol
• Roxera
• Ineji

If you have had a blood test that shows that your cholesterol levels are elevated, be sure to consult your doctor. He will give recommendations on nutrition and lifestyle adjustments. If necessary, he will prescribe the most effective cholesterol pills that will reduce the risk of developing dangerous diseases.

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is a blood test for cholesterol, and if it shows a high level of only “bad” or total cholesterol, you should take this seriously and do everything to reduce these levels.

For some people, to reduce cholesterol, it is enough to change their lifestyle (diet and more physical activity), but for others whose levels are too high, they need to add drug treatment. If your doctor has prescribed you medications to lower cholesterol levels, take them according to a clearly indicated schedule and do not skip them, because your health depends on it.

There are different groups of drugs to normalize cholesterol .

Statins.

They are suitable for most patients, and they are the only drugs that directly reduce the risk of heart attack or stroke. If statins do not help you or there are unwanted side effects, your doctor will help you choose cholesterol pills from a different group.

PCSK9 inhibitors.

Drugs in this group for lowering “bad” cholesterol deactivate the protein in the liver. PCSK9 inhibitors are often prescribed in parallel with statins.

Selective cholesterol absorption inhibitors.

This is a relatively new group of drugs that interfere with the absorption of cholesterol in the intestines. SIACs are most effective in reducing the level of “bad” cholesterol, and can also increase “good” cholesterol. Such medications are prescribed for high cholesterol levels, as well as for some hereditary problems with lipid metabolism.

Resins.

This group of cholesterol-lowering drugs is also called bile acid sequestrants or bile acid binders. Resins act in the intestines, helping to remove cholesterol. Our body uses cholesterol to produce bile. If the level of bile in the gastrointestinal tract is insufficient, the liver will stimulate its production, and the more bile produced, the more cholesterol the liver needs. As a result, less of it will circulate in the blood.

Fibrates.

These drugs are very good at lowering triglyceride levels and often normalize the “good” level. At the same time, fibrates have virtually no effect on “bad” cholesterol.

Niacin (nicotinic acid, vitamin PP or B3).

This substance affects the production of fats by working in the liver. When taking drugs from this group, it is necessary to monitor liver function, since niacin is toxic. Side effects include: upset stomach, redness, itching. Patients with diabetes should take the drug with caution, as it may increase blood sugar levels.

Omega-3 ethyl esters.

Cholesterol drugs in this group are made from fish oil (modified and purified). Prescribed against the background of a special diet to reduce cholesterol levels. Serious side effects may occur in patients with allergies to fish or shellfish.

Fish oil with omega-3 polyunsaturated fatty acids (PUFAs).

These supplements are also called omega-3 acids and are prescribed to lower triglyceride levels.

All of the above drugs should be prescribed exclusively by a doctor, because there are contraindications and side effects with large doses of such drugs. Dangerous side effects include hemorrhagic stroke and sugar spikes in diabetics.

In Russia, doctors usually prescribe statins to lower cholesterol levels, so let’s talk about drugs from this group.

What foods increase cholesterol: what should you avoid?

When cholesterol levels in the blood exceed the norm, the first thing doctors prescribe is a change in the usual diet. No drug can help if a person continues to eat food that contains “bad” cholesterol.

It is necessary to create a diet that will include:

• Dishes baked, steamed, boiled or stewed.
• Variety of vegetables, fruits, berries and herbs.
• Lean meat, fish and seafood.
• A wide range of cereals and dishes made from cereals and legumes.
• Products high in Omega-3 fats.

When creating a diet, you can also use some types of dairy products. But you should be extremely careful with milk, kefir, yogurt, sour cream, as they often contain a high level of fat content.

The following products should be excluded:

• Protein of animal origin (fatty meats and fish, broths based on them, dry rations, caviar, high-fat milk).
• Trans fats and preservatives (mayonnaise, ready-made sauces, margarine, chips, fast food, carbonated drinks).
• Protein of plant origin (various varieties of mushrooms, soups and broths based on them).
• Caffeine-containing products (coffee, tea, energy drinks, chocolates).
• Simple carbohydrates (chocolate, confectionery, baked goods).
• Salt, pepper and other seasonings.

Atoris

This cholesterol-lowering drug comes in tablet form and is available by prescription. The active substance is atorvastatin. "Atoris" is a third-generation cholesterol-lowering medicine and, when taken in a course, helps to cope with the problem. Typically, this drug is prescribed for severe forms of hypercholesterolemia, hereditary high cholesterol, etc. Atoris is indicated for diseases of the cardiovascular system, high risks of coronary artery disease and heart attack.

Cholesterol pills are generally well tolerated, although they do have side effects: joint pain, digestive problems, constipation, muscle pain, liver problems and increased blood sugar.

Contraindications include pregnancy, breastfeeding, serious liver and kidney diseases. In parallel with taking Atoris, you should not drink grapefruit juice or eat the fruit itself.

Atoris

JSC "Biolek", Ukraine

hypercholesterolemia: - as an adjunct to diet to reduce elevated total cholesterol, LDL-C, apo-B and TG in plasma in adult patients, adolescents and children aged 10 years or older with primary hypercholesterolemia, including familial hypercholesterolemia (heterozygous) or combined (mixed) hyperlipidemia (type IIa and IIb, respectively, according to the Fredrickson classification), when the response to diet and other non-drug treatment methods is insufficient;
- to reduce elevated total cholesterol, plasma LDL cholesterol in adult patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (for example, LDL apheresis), or if such treatments are not available. prevention of cardiovascular diseases: - prevention of cardiovascular events in adult patients at high risk of developing primary cardiovascular events, as an addition to the correction of other risk factors; — secondary prevention of cardiovascular complications in pa from 196

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Livazo

These fourth generation high cholesterol pills are available by prescription. The active substance of Livazo is pitavastatin. This cholesterol medicine is best suited for people with diabetes: it does not increase blood sugar levels or affect glucose metabolism. It is very important to choose the right dose of the drug to prevent unwanted serious reduction in cholesterol.

Livazo

Pierre Fabre, Switzerland

- primary hypercholesterolemia, including heterozygous familial hypercholesterolemia (hyperlipidemia type IIa according to Fredrickson classification) or mixed hypercholesterolemia (hyperlipidemia type IIb according to Fredrickson classification), hypertriglyceridemia (hyperlipidemia type IV according to Fredrickson classification) as an addition to diet, when diet and other non-drug treatments (eg exercise, weight loss) are insufficient.
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Helpful tips for fighting cholesterol

In addition to proper nutrition, several simple actions that can become a good tradition can reduce the amount of cholesterol in the blood.

Increase the amount of physical activity, physical activity and sports. Choose loads that are suitable for your age and health. Those who don't exercise at all can start with leisurely walks, then move on to brisk walking and eventually start running.

Give up bad habits. Minimize the amount of alcohol and tobacco in your life. In addition to affecting the heart and vascular system, these addictions also negatively affect other organs.

Author: Di&Di Corporation

Ezetrol

The tablets can be purchased with a prescription, and the active ingredient in the cholesterol drug is ezetimibe. "Ezetrol" selectively prevents the absorption of cholesterol. This is a new generation medicine that does not stimulate the secretion of bile acids and does not inhibit cholesterol synthesis in the liver. The main effect of Ezetrol is aimed at reducing the flow of bile acids from the intestines to the liver. Thus, cholesterol reserves are reduced and it is intensively removed from the blood. "Ezetrol" is indicated for diabetes mellitus and various causes of high cholesterol.

Side effects include changes in blood tests, allergies and diarrhea. This drug is contraindicated during pregnancy, breastfeeding, and serious liver diseases.

Ezetrol

Schering-Plough, Switzerland

Primary hypercholesterolemia (in combination with statins or as monotherapy in addition to diet to reduce elevated levels of total cholesterol, LDL cholesterol, apolipoprotein B and triglycerides, as well as to increase HDL cholesterol levels in patients with primary hypercholesterolemia);
homozygous familial hypercholesterolemia (in combination with statins it is recommended to reduce elevated levels of total cholesterol, LDL cholesterol, and the use of LDL apheresis is also possible); homozygous sitosterolemia (or phytosterolemia) - increased levels of plant sterols in plasma with elevated or normal levels of cholesterol and normal triglycerides. from 1024

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Roxera

Cholesterol-lowering tablets are available by prescription and the active ingredient is rosuvastatin. This is the most modern drug of the fourth generation, which has a minimum of side effects. “Roxera” reduces “bad” cholesterol and normalizes “good” cholesterol, cleanses blood vessels of fat deposits and reduces the risk of the formation of cholesterol “plaques”.

This drug is prescribed for the prevention of atherosclerosis with negative heredity in this regard; for the treatment of atherosclerosis, which already exists, as well as its complications. The huge advantage of the drug is that it helps not only fight atherosclerosis, but also relieves inflammation in blood vessels.

"Roxera" should be taken with caution if you have liver disease; taking this medicine during pregnancy and lactation is prohibited. You should not take alcohol or any antibiotics if you are taking Roxera.

Roxera

KRKA (KRKA), Slovenia

- primary hypercholesterolemia (Fredrickson type IIa) or mixed dyslipidemia (Fredrickson type IIb) as an addition to diet when diet and other non-drug treatments (for example, exercise, weight loss) are ineffective;
- familial homozygous hypercholesterolemia as an addition to diet and other lipid-lowering therapy (for example, LDL apheresis) or if such therapy is not effective; - hypertriglyceridemia (type IV according to Fredrickson) as an addition to the diet; - to slow the progression of atherosclerosis as an addition to the diet in patients who are indicated for therapy to reduce plasma concentrations of cholesterol and LDL cholesterol; - primary prevention of major cardiovascular complications (stroke, myocardial infarction, arterial revascularization) in adult patients without clinical signs of coronary artery disease, but with an increased risk of its development (age over 50 years for men and over 60 years for women, increased plasma concentration of C- reactive protein (≥2 g/l) if present, minimum 275

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Review of 4 pharmaceutical drugs

The modern pharmaceutical industry produces herbal dietary supplements that help fight high cholesterol. Such components have pronounced effectiveness according to research data.

The most effective options are described below:

1. Atheroclephitis BIO. Contains clover extract, ascorbic and nicotinic acids, hawthorn flowers and leaves, rutin and calcium stearate. The drug helps normalize cholesterol metabolism, increase the functional activity of arteries and maintain the rheological properties of blood at the proper level. It is recommended to use 1 capsule twice a day with meals. The duration of treatment is 30 days.
2. CardioActive TAURINE. The main element of the drug, taurine, is of plant origin. Improves metabolic processes in the heart muscle, reduces total peripheral vascular resistance and TAG concentration in the blood, protects the eyes from diabetic and hypertensive retinopathy. You should take 1 capsule (0.5 g) 1 time per day.
3. Curcumin. The main active ingredient is turmeric extract. Helps remove “pathogenic” cholesterol from the body, strengthen the immune system, and suppress any inflammatory processes. Directions for use: 1 capsule during meals 3 times a day. The course of treatment is 1 month.
4. Revaitl Garlic Pearls. The action of the product is based on the effects of garlic (in particular allicin) and peanut oils. Reduces LDL and TAG, increases HDL, inhibits the mechanisms of atherogenesis of the vascular bed. You need to take 2 capsules 3 times a day. The duration of therapy is no more than 42 days.

Ineji

These high cholesterol pills are also available with a prescription only. Ineji belongs to a new group of drugs - statins with cholesterol absorption inhibitors. The active ingredients of Ineji are simvastatin and ezetimibe. The medicine does an excellent job of reducing “bad” cholesterol.

Ineji is prescribed for the prevention of cardiovascular diseases, for coronary heart disease, after a stroke or heart attack (to prevent recurrent ones), for severely elevated lipids and hereditary problems with cholesterol.

Contraindications: allergic reactions, liver diseases, pregnancy, breastfeeding, age under 18 years, lactase deficiency. Side effects: depression, dizziness, joint pain, nausea, memory problems.

Ineji

Side effects

Numerous negative effects may occur after administration:

• Frequent side effects: asthenia , insomnia , headache , constipation , nausea , abdominal pain, diarrhea , myalgia , flatulence .
• Digestive system: diarrhea, vomiting, hepatitis, pancreatitis , cholestatic jaundice, anorexia .
• Nervous system: dizziness , amnesia, hypoesthesia, malaise, paresthesia, peripheral neuropathy.
• Allergic manifestations: rash and itching of the skin , urticaria , anaphylaxis , exudative erythema, Lyell's syndrome.
• Musculoskeletal system: back pain, myositis , cramps , arthritis , myopathy .
• Hematopoiesis: thrombocytopenia .
• Metabolic processes: hypoglycemia , diabetes mellitus , weight gain, obesity , impotence , peripheral edema.
• The most severe complication of statin treatment is rhabdomyolysis , but this occurs in rare cases.