Concor - treatment of arterial hypertension and heart rhythm disturbances

Description of tablets "Concor"

"Concor" is a medication that is used to treat low blood pressure, sore throat, and also to normalize heart rhythm. The active ingredient is 2 compounds:

1. Bisoprolol fumarate.
2. Bisoprolol hemifumarate.

Available in the form of tablets, each of which contains 5 or 10 mg of the main component. Dispensed in pharmacies only with a prescription. Can be stored under normal conditions (at a temperature not exceeding 30 degrees) for the total shelf life (5 years from the date of production).

Release form

Concor tablets are coated with a light orange shell, heart-shaped, biconvex, with serifs on both edges.

Release forms for Concor (dosage 5 and 10 mg):

• ten such tablets in a blister, five or three such blisters in a cardboard package;
• or 25 such tablets in a blister, two such blisters in a cardboard package;
• or 30 such tablets in a blister, one such blister in a cardboard package.

For Concor 10 mg there is additionally the following release form:

• 30 tablets in a blister, three such blisters in a cardboard package.

Contraindications

In some cases, taking the drug is prohibited:

• exacerbation of heart failure;
• a sharp decrease in pressure;
• cardiogenic shock;
• acidosis;
• intolerance to individual components, allergic reactions;
• bronchial asthma;
• blockade (sinoatrial and AV type).

The product is indicated for use only in adult patients. Children under the age of 17 inclusive are prohibited from using Concor. In this case, the pediatrician must develop a different course of therapy.

Attention!

Taking the product during pregnancy and breastfeeding (at any stage) is allowed, but with caution. There are no reported cases of complications, but therapy should be agreed with a doctor.

Pharmacological properties of the drug Concor cor

Bisoprolol (INN - bisoprololum) is a selective β1-adrenergic receptor blocker. When used in therapeutic doses, it does not have BSA and clinically significant membrane-stabilizing properties. Reduces plasma renin activity, reduces myocardial oxygen demand, and reduces heart rate (at rest and during exercise). By blocking β1-adrenergic receptors of the heart in low doses, it reduces the catecholamine-stimulated formation of cAMP from ACE, reduces the intracellular current of calcium ions, and has a negative chrono-, dromo- and inotropic effect (inhibits conduction excitability, slows down AV conduction). The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate, a slight decrease in contractility, prolongation of diastole, and improved myocardial perfusion. When increasing the dose above the therapeutic one, it has a β2-adrenergic blocking effect. Concor Cor has a hypotensive effect due to a decrease in cardiac output, inhibition of renin secretion by the kidneys, as well as an effect on the baroreceptors of the aortic arch and carotid sinus. In case of hypertension (arterial hypertension), the effect occurs after 2–5 days, stable effect occurs after 1–2 months. With prolonged use, bisoprolol reduces increased peripheral vascular resistance. When used in average therapeutic doses, in contrast to non-selective β-blockers, it has a less pronounced effect on organs containing β2-adrenergic receptors (pancreas, skeletal muscles, smooth muscles of peripheral arteries, bronchi and uterus) and on carbohydrate metabolism, does not cause delay sodium ions (Na+) in the body. The severity of the atherogenic effect does not differ from the effect of propranolol. After taking the drug orally, bisoprolol is well absorbed from the gastrointestinal tract. Bioavailability is about 90% and is independent of food intake. The maximum concentration is reached after 1–3 hours. Binding to blood plasma proteins is about 30%. The effect of primary passage through the liver is insignificant (about 10%). About 50% of bisoprolol is biotransformed in the liver with the formation of inactive metabolites. The main metabolites found in blood plasma and urine do not exhibit pharmacological activity. The pharmacokinetics of bisoprolol is linear. Its concentration in blood plasma is proportional to the administered dose in the dose range from 5 to 20 mg. The maximum concentration in blood plasma is reached after 2–3 hours. Bisoprolol is distributed quite widely. The volume of distribution is 3.5 l/kg. Communication with blood plasma proteins is about 35%. The total clearance is 15.6 ± 3.2 l/h, with renal clearance being 9.6 ± 1.6 l/h. The half-life is 10–12 hours. Approximately 98% is excreted from the body in the urine, 50% unchanged, the rest in the form of metabolites, approximately 2% of the dose is excreted in the feces. No dose adjustment is required for patients with mild to moderate hepatic or renal impairment.

Side effects

Side effects are rare, but they are not excluded:

• cramps, muscle weakness;
• bronchial asthma (exacerbation);
• sleep disorders;
• depressive states;
• headaches;
• dizziness;
• rarely – loss of consciousness;
• conjunctivitis;
• nausea;
• diarrhea;
• problems with potency;
• allergic reactions (itching, rashes, rhinitis of allergic origin).

Instructions for use of "Concor" tablets

The drug is started with a small dose - 5 mg per day. If necessary, it can be increased to 10 mg. If the patient suffers from high blood pressure or angina pectoris, a maximum amount of 20 mg per day can be taken. In case of chronic heart failure (without acute periods) – 10 mg.

"Concor" is taken as a primary or additional means. It is often used in conjunction with blockers of diuretics, cardiac glycosides, and ACE inhibitors. The course of treatment is long until the desired effect is achieved. Specific terms are not specified in the instructions, so the patient should consult a doctor before starting treatment.

Important!

During treatment, alcohol intake is completely contraindicated. If possible, you should reduce or quit smoking. In consultation with your doctor, you need to follow a certain diet.

Analogs

When choosing analogues, it is important to understand that each of them has its own indications for use, side effects, contraindications, active substances, etc. It is important to consult a doctor and not change the drug yourself.

Which is better: Concor, Bisoprolol, Coronal?

All of these drugs contain the same active substance - bisoprolol. They have similar contraindications and indications for use.

Bisoprolol is used to treat arterial hypertension, tachycardic heart rhythm disorders, ischemia, heart failure and various forms of arrhythmia. It is considered antihypertensive and lowers blood pressure. Patients whose blood pressure is 90 mm or lower (hypotension) are prohibited from taking Bisoprolol. It is easier to tolerate by patients and there is less risk of complications when taking it. This applies to diabetes mellitus, respiratory tract diseases, and hypotension.

Coronal is a generic version of Concor, that is, it has the same spectrum of pharmacological action as the original drug, but differs in strength. Coronal also reduces pain and blood pressure, improves blood supply to the heart muscle, and normalizes heart rhythm. But Coronal does not have such a noticeable effect on the patient’s heart rate.

Which is better: Concor, Betalok Zok, Betalok or Egilok?

The active ingredient in the drugs Betalok ZOK, Betalok and Egilok is the same - metoprolol.

The effectiveness of Concor and Betaloc ZOK in reducing blood pressure and stopping attacks of tachycardia is the same. The duration of the therapeutic effect lasts more than a day. But only a cardiologist has the right to prescribe Concor or Betaloc ZOK, having studied the risk factors, medical history and individual sensitivity of the patient to the components of the drug.

Betaloc is a medicine for hypertension, angina and heart failure. Today it is considered obsolete. He was replaced by Betalok ZOK.

Egilok, like Concor, is effective for high blood pressure, but since the active components are different, there are differences. Compared to Concor, Egilok acts very quickly (15-20 minutes after taking the tablet), but this means that the duration of the therapeutic effect is not so long. The drug should be taken two to three times a day during or after meals.

Which is better: Concor, Nebivolol or Nebilet?

The drugs have a positive effect on the heart with high blood pressure, chronic heart failure, ischemia, tachycardia, but Nebilet and its almost complete analogue Nebivolol are based on the active component - nebivolol, which is capable of dilating peripheral vessels and reducing cardiac output. This adds to its effectiveness as an antihypertensive agent.

The active substance nebivolol promotes the production of nitric oxide, which relaxes blood vessels for a longer period. Unlike Concor, it does not contribute to the patient’s weight gain. Since nebivolol dilates blood vessels, it acts faster, but the effect does not last long.

Nebilet and differing from it solely in the degree of purification and, accordingly, in price, Nebivolol is also used for hypertension and coronary heart disease. But it is contraindicated in patients with low blood pressure, cardiogenic shock, severe heart failure, diseases of the respiratory system and liver. Not for use by children, pregnant and lactating women. Treatment should not be started if you have diabetes, thyroid dysfunction, psoriasis or in old age. Concor is safer for the elderly, children and patients with breathing problems.

Concor or Sotahexal

The active ingredient in Sotahexal, sotalol hydrochloride, copes well with arrhythmia and lowers blood pressure. Contraindicated for use in patients with hypotension.

Sotahexal can cause side effects in the form of bronchospasms, disorders of carbohydrate and lipid metabolism.

Concor, compared to Sotahexal, is easier to tolerate and more effective for patients suffering from chronic heart failure. Also, Concor has a lower risk of complications. This applies to diabetes mellitus (Sotahexal increases hypoglycemia), respiratory diseases, and hypotension. But Sotahexal is more often prescribed for arrhythmic disorders.

Cases of overdose

In case of overdose, there is a severe drop in blood pressure and other dangerous consequences:

• exacerbation of heart failure;
• hypoglycemia;
• bronchospasm;
• AV block;
• bradycardia.

Treatment is symptomatic, depending on the nature of the exacerbation. For example, to relieve the symptoms of bradycardia, atropine is administered, and in case of glycemia, a glucose solution is administered. If bronchospasm is observed, it is treated with Aminophylline. In case of a serious condition, it is necessary to call emergency assistance as quickly as possible.

Reviews about Concor

Reviews from doctors about Concor blood pressure pills generally fit into the average statistical picture of reports about beta-blockers. The drug has its advantages and disadvantages.

The forums also contain ample assessments of the effectiveness of the drug. The most frequently asked question: do Concor tablets reduce blood pressure? It should be remembered that effectiveness highly depends on the individual characteristics of each individual patient.

Nebilet or Concor - which is better?

Both drugs belong to the group of beta-blockers. Nebilet, from a theoretical point of view, has a stronger vasodilatory effect and is more likely to cause undesirable effects (headaches) due to excessive vasodilating effects. In this case, the drug of choice is Concor.

Egilok or Concor - which is better?

The products are similar in almost all respects. One drug can be easily replaced with another during treatment. 5 mg of Concor is equivalent to 50 mg of Egilok.

Lokren or Concor - which is better?

Compared to Concor, Lokren has a more prolonged effect, greater affinity for specific receptors and, therefore, the most stable plasma concentration. Medicine prices are comparable.

Coronal or Concor - which is better?

These products are interchangeable analogues with the same active ingredient. Coronal is more affordable from a financial point of view, so the choice between drugs should be made based on considerations of economic feasibility and the individual characteristics of the patient.

Bisoprolol or Concor - which is better?

The answer to this question is identical to the previous answer. These drugs are analogues, but Bisoprolol has a lower price.

What is the difference between Concor Cor and Concor?

The most common question about the comparative effectiveness of drugs: what is the difference between Concor and Concor Cor ? Bisoprolol as an active ingredient . The main difference between the drugs is the presence of tablets with a dosage of 2.5 mg in Concor Cor.

Drug interactions

The drug is not recommended to be combined with medications such as Bisopropol. It leads to a decrease in the conductivity and contractility of the heart, which can lead to bradycardia. In turn, this will lead to vasodilation.

With caution, Concor is combined with drugs based on amiodarone and parasympathomimetic agents. If you use hypoglycemic drugs, their effect will increase. If used together with cardiac glycosides, symptoms of bradycardia will appear.

Parallel use of adrenergic agonists leads to an increase in blood pressure. If you use Mefloquine at the same time, this will again cause symptoms of bradycardia.

Concor price, where to buy

In Russia, the price of Concor 5 mg No. 50 ranges from 306-340 rubles; buying 50 tablets of 10 mg will cost 463-575 rubles. The cost of the medicine (5 mg No. 50) in Moscow starts from 313 rubles.

The price of Concor tablets in Ukraine 10 mg No. 50 averages 162 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Concor KOR tablets p.p.o.
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  RUR 708 order

• Concor AM tablets 5mg+5mg 30 pcs. JSC Pharmaceutical Plant EGIS

  RUR 414 order

• Concor tab. p/o captivity. 5 mg 50 pcs. Nanolek LLC

  RUB 287 order

• Concor tablets p.p.o. 10 mg 50 pcs. Merck KGaA/LLC Nanolek

  RUR 431 order

Pharmacy Dialogue

• Concor (table 5 mg No. 50) Merck KgaA

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• Concor (table 5 mg No. 30) Merck KgaA

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Pharmacy24

• Concor 5 mg N30 tablets Merck KGaA, Nimechchina
  108 UAH order
• Concor 5 mg N50 tablets Merck KGaA, Nimechchina

  159 UAH order

• Concor 10 mg No. 30 tablets Merck KGaA, Nimechchina

  168 UAH order

• Concor Cor 2.5 mg No. 30 tablets Merck KGaA, Nimechchina

  95 UAH order

• Concor 10 mg N50 tablets Merck KGaA, Nimechchina

  292 UAH. order

PaniPharmacy

• Concor tablets Concor tablets. 10 mg No. 50 Germany, Merck KGaA

  300 UAH order

• Concor tablets Concor tablets. 5mg No. 30 Germany, Merck KGaA

  127 UAH order

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• Concor tablets Concor tablets. 10 mg No. 30 Germany, Merck KGaA

  191 UAH order

• Concor cor tablets Concor cor tablets, film-coated 2.5 mg No. 30 Germany, Merck KGaA

  103 UAH order

• Concor tablets Concor tablet 5mg No. 50 Germany, Merck KGaA

  167 UAH order

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special instructions

In some cases, there are no direct contraindications to the use of Concor. However, it should be taken with caution if you have the following disorders:

• following a strict diet (for example, after surgery, to correct weight);
• psoriasis;
• diabetes mellitus (if its course is accompanied by hypoglycemia);
• Prinzmetal's angina;
• AV block (first degree).